Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.54 |
| ▸ | HTR3B | O95264 | 1/20 | 0.54 |
| ▸ | HTR3A | P46098 | 1/20 | 0.54 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.54 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.54 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.53 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.44 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | BTK | Q06187 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6629827 | 0.82 | HTR3E (0.61) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL15088204 | 0.81 | ALDH1A1 (0.53) | HSD17B1HSD17B2BTKALDH1A1FGFR4 | |
| SCHEMBL19890630 | 0.81 | HSD17B1 (0.51) | HSD17B1HSD17B2BTKTP53LMNA | |
| SCHEMBL11756402 | 0.80 | BTK (0.46) | BTKGPBAR1 | |
| SCHEMBL29989323 | 0.80 | BTK (0.46) | BCL2A1BTKALDH1A1FGFR4 | |
| SCHEMBL15974825 | 0.80 | BTK (0.46) | BCL2A1BTKALDH1A1FGFR4 | |
| SCHEMBL10194675 | 0.79 | BCL2A1 (0.49) | BCL2A1MAPTALDH1A1HPGDGPBAR1 | |
| SCHEMBL31715773 | 0.79 | HTR3E (0.61) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL2096198 | 0.79 | HTR3E (0.61) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL2096196 | 0.79 | HTR3E (0.61) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1124795-A1 | INHIBITORS OF THE EGF-RECEPTOR TYROSINE KINASE AND THEIR USE | Parker Hughes Institute (US) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000056703-A1 | INHIBITORS OF THE EGF-RECEPTOR TYROSINE KINASE AND THEIR USE | PARKER HUGHES INSTITUTE (US) | 2000-09-28 | — | — | WO | disclosed |