Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.59 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 7/20 | 0.59 |
| ▸ | KDR | P35968 | 1/20 | 0.59 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.54 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.54 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.54 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.54 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14693849 | 0.84 | NPC1 (0.55) | KMT2ARAB9ANPC1POLBSMN1; SMN2 | |
| SCHEMBL14693923 | 0.81 | GRM5 (0.65) | KMT2ARAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL14693968 | 0.79 | KMT2A (0.67) | KMT2ARAB9ANPC1POLBMEN1 | |
| SCHEMBL14693863 | 0.79 | KCNQ3 (0.60) | KMT2ARAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL12750400 | 0.78 | KCNQ3 (0.54) | KMT2ARAB9ANPC1POLBMEN1 | |
| SCHEMBL9767122 | 0.78 | RAB9A (0.71) | KMT2ARAB9ANPC1POLBCACNA1B | |
| SCHEMBL18146518 | 0.78 | KMT2A (0.62) | KMT2ARAB9ANPC1POLBCACNA1B | |
| SCHEMBL14693882 | 0.76 | GRM5 (0.55) | KMT2AMEN1IRAK4 | |
| SCHEMBL30641944 | 0.75 | RAB9A (0.60) | KMT2ARAB9ANPC1POLBCACNA1B | |
| SCHEMBL27704227 | 0.75 | RAB9A (0.60) | KMT2ARAB9ANPC1POLBCACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560008-B1 | Pharmaceutical compositions for preventing or treating degenerative brain disease and method of screening the same | KOREA INST SCI & TECH (KR) | 2016-11-30 | — | — | EP | disclosed |
| EP-2560008-B1 | Pharmaceutical compositions for preventing or treating degenerative brain disease and method of screening the same | KOREA INST SCI & TECH (KR) | 2016-11-30 | — | — | EP | disclosed |
| US-9469653-B2 | Pharmaceutical compositions for preventing or treating degenerative brain disease and method of screening the same | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2016-10-18 | — | — | US | disclosed |
| US-9469653-B2 | Pharmaceutical compositions for preventing or treating degenerative brain disease and method of screening the same | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2016-10-18 | — | — | US | disclosed |
| US-20140142089-A1 | PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING DEGENERATIVE BRAIN DISEASE AND METHOD OF SCREENING THE SAME | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2014-05-22 | — | — | US | disclosed |
| US-20140142089-A1 | PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING DEGENERATIVE BRAIN DISEASE AND METHOD OF SCREENING THE SAME | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2014-05-22 | — | — | US | disclosed |
| US-20130046093-A1 | PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING DEGENERATIVE BRAIN DISEASE AND METHOD OF SCREENING THE SAME | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2013-02-21 | — | — | US | disclosed |
| US-20130046093-A1 | PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING DEGENERATIVE BRAIN DISEASE AND METHOD OF SCREENING THE SAME | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2013-02-21 | — | — | US | disclosed |
| EP-2560008-A2 | Pharmaceutical compositions for preventing or treating degenerative brain disease and method of screening the same | Korea Institute of Science and Technology (KR) | 2013-02-20 | — | — | EP | disclosed |
| EP-2560008-A2 | Pharmaceutical compositions for preventing or treating degenerative brain disease and method of screening the same | Korea Institute of Science and Technology (KR) | 2013-02-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140142089-A1 | PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING DEGENERATIVE BRAIN DISEASE AND METHOD OF SCREENING THE SAME | PSEN2, PSEN1, GRN | KMT2A 4162/4885RAB9A 3634/4885NPC1 112/4885 |
| US-20130046093-A1 | PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING DEGENERATIVE BRAIN DISEASE AND METHOD OF SCREENING THE SAME | PSEN2, PSEN1, GRN | KMT2A 4162/4885RAB9A 3634/4885NPC1 112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.