Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | MITF | O75030 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14693792 | 0.84 | KMT2A (0.62) | NPC1KDRMAPTALDH1A1MEN1 | |
| SCHEMBL25489494 | 0.83 | NPC1 (0.49) | NPC1KDRMAPTALDH1A1MMP13 | |
| SCHEMBL14693909 | 0.82 | RAB9A (0.60) | NPC1KDRMEN1KMT2APOLB | |
| SCHEMBL29030365 | 0.81 | ABCG2 (0.49) | NPC1KDRMAPTALDH1A1MMP13 | |
| SCHEMBL14693774 | 0.80 | KCNQ3 (0.57) | NPC1ALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL14693827 | 0.80 | RAB9A (0.56) | NPC1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL14693921 | 0.80 | MAPT (0.56) | NPC1MAPTMEN1KMT2APOLB | |
| SCHEMBL6965899 | 0.80 | NPC1 (0.70) | NPC1KDRMAPTALDH1A1MEN1 | |
| SCHEMBL12750400 | 0.79 | KCNQ3 (0.54) | NPC1KDRMAPTALDH1A1MEN1 | |
| SCHEMBL11469609 | 0.77 | MAPT (0.65) | NPC1KDRMAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560008-B1 | Pharmaceutical compositions for preventing or treating degenerative brain disease and method of screening the same | KOREA INST SCI & TECH (KR) | 2016-11-30 | — | — | EP | disclosed |
| EP-2560008-B1 | Pharmaceutical compositions for preventing or treating degenerative brain disease and method of screening the same | KOREA INST SCI & TECH (KR) | 2016-11-30 | — | — | EP | disclosed |
| US-9469653-B2 | Pharmaceutical compositions for preventing or treating degenerative brain disease and method of screening the same | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2016-10-18 | — | — | US | disclosed |
| US-9469653-B2 | Pharmaceutical compositions for preventing or treating degenerative brain disease and method of screening the same | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2016-10-18 | — | — | US | disclosed |
| US-20140142089-A1 | PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING DEGENERATIVE BRAIN DISEASE AND METHOD OF SCREENING THE SAME | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2014-05-22 | — | — | US | disclosed |
| US-20140142089-A1 | PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING DEGENERATIVE BRAIN DISEASE AND METHOD OF SCREENING THE SAME | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2014-05-22 | — | — | US | disclosed |
| US-20130046093-A1 | PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING DEGENERATIVE BRAIN DISEASE AND METHOD OF SCREENING THE SAME | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2013-02-21 | — | — | US | disclosed |
| US-20130046093-A1 | PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING DEGENERATIVE BRAIN DISEASE AND METHOD OF SCREENING THE SAME | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2013-02-21 | — | — | US | disclosed |
| EP-2560008-A2 | Pharmaceutical compositions for preventing or treating degenerative brain disease and method of screening the same | Korea Institute of Science and Technology (KR) | 2013-02-20 | — | — | EP | disclosed |
| EP-2560008-A2 | Pharmaceutical compositions for preventing or treating degenerative brain disease and method of screening the same | Korea Institute of Science and Technology (KR) | 2013-02-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140142089-A1 | PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING DEGENERATIVE BRAIN DISEASE AND METHOD OF SCREENING THE SAME | PSEN2, PSEN1, GRN | NPC1 112/4885KDR 4630/4885MAPT 19/4885 |
| US-20130046093-A1 | PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING DEGENERATIVE BRAIN DISEASE AND METHOD OF SCREENING THE SAME | PSEN2, PSEN1, GRN | NPC1 112/4885KDR 4630/4885MAPT 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.