Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 12/20 | 0.79 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.79 |
| ▸ | ABCC1 | P33527 | 4/20 | 0.62 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.55 |
| ▸ | CASP7 | P55210 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.50 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.48 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14708630 | 0.86 | ABCG2 (0.79) | ABCG2ABCB1ABCC1TP53MAPT | |
| SCHEMBL14697069 | 0.84 | ABCG2 (0.74) | ABCG2ABCB1ABCC1TP53MAPT | |
| SCHEMBL14697214 | 0.84 | ABCG2 (0.85) | ABCG2ABCB1ABCC1TP53MAPT | |
| SCHEMBL1977218 | 0.83 | ABCG2 (0.53) | ABCG2ABCB1TP53MAPTKDM4E | |
| SCHEMBL1979055 | 0.81 | ABCG2 (0.52) | ABCG2ABCB1ABCC1TP53MAPT | |
| SCHEMBL14696999 | 0.80 | MAPT (0.60) | ABCG2ABCB1TP53MAPTKDM4E | |
| SCHEMBL8850238 | 0.80 | MAPT (0.53) | ABCG2ABCB1TP53MAPTKDM4E | |
| SCHEMBL1973404 | 0.79 | MAPT (0.58) | ABCG2ABCB1TP53MAPTKDM4E | |
| SCHEMBL1977887 | 0.79 | MAPT (0.58) | ABCG2ABCB1TP53MAPTKDM4E | |
| SCHEMBL1421811 | 0.79 | MAPT (0.61) | ABCG2ABCB1TP53MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140186329-A1 | POLYPHENOL ANALOGS TO TREAT ISCHEMIA | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-07-03 | — | — | US | claimed |
| US-20140186328-A1 | NEUROPROTECTIVE POLYPHENOL ANALOGS | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2014-07-03 | — | — | US | claimed |
| EP-2741609-A1 | NEUROPROTECTIVE POLYPHENOL ANALOGS | Salk Institute for Biological Studies (US) | 2014-06-18 | — | — | EP | claimed |
| WO-2013025484-A1 | POLYPHENOL ANALOGS TO TREAT ISCHEMIA | LAPCHAK PAUL A (US) | 2013-02-21 | — | — | WO | claimed |
| WO-2013025498-A1 | NEUROPROTECTIVE POLYPHENOL ANALOGS | SCHUBERT DAVID R (US) | 2013-02-21 | — | — | WO | claimed |
| US-9744164-B2 | Neuroprotective polyphenol analogs | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2017-08-29 | — | — | US | disclosed |
| US-9744164-B2 | Neuroprotective polyphenol analogs | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2017-08-29 | — | — | US | disclosed |
| US-9744164-B2 | Neuroprotective polyphenol analogs | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2017-08-29 | — | — | US | disclosed |
| US-20160206609-A1 | NEUROPROTECTIVE POLYPHENOL ANALOGS | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2016-07-21 | — | — | US | disclosed |
| US-20160206609-A1 | NEUROPROTECTIVE POLYPHENOL ANALOGS | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2016-07-21 | — | — | US | disclosed |
| US-20140186328-A1 | NEUROPROTECTIVE POLYPHENOL ANALOGS | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2014-07-03 | — | — | US | disclosed |
| US-20140186329-A1 | POLYPHENOL ANALOGS TO TREAT ISCHEMIA | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-07-03 | — | — | US | disclosed |
| US-20140186329-A1 | POLYPHENOL ANALOGS TO TREAT ISCHEMIA | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-07-03 | — | — | US | disclosed |
| US-20140186328-A1 | NEUROPROTECTIVE POLYPHENOL ANALOGS | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2014-07-03 | — | — | US | disclosed |
| EP-2741609-A1 | NEUROPROTECTIVE POLYPHENOL ANALOGS | Salk Institute for Biological Studies (US) | 2014-06-18 | — | — | EP | disclosed |
| WO-2013025484-A1 | POLYPHENOL ANALOGS TO TREAT ISCHEMIA | LAPCHAK PAUL A (US) | 2013-02-21 | — | — | WO | disclosed |
| WO-2013025498-A1 | NEUROPROTECTIVE POLYPHENOL ANALOGS | SCHUBERT DAVID R (US) | 2013-02-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140186329-A1 | POLYPHENOL ANALOGS TO TREAT ISCHEMIA | GPX1, KEAP1, GPX4 | ABCG2 4578/4885ABCB1 4736/4885ABCC1 3205/4885 |
| US-20140186328-A1 | NEUROPROTECTIVE POLYPHENOL ANALOGS | GSR, IAPP, GCLC | ABCG2 1504/4885ABCB1 2707/4885ABCC1 2547/4885 |
| US-20160206609-A1 | NEUROPROTECTIVE POLYPHENOL ANALOGS | GSR, IAPP, GCLC | ABCG2 1504/4885ABCB1 2707/4885ABCC1 2547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.