Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 19/20 | 0.49 |
| ▸ | INSR | P06213 | 6/20 | 0.47 |
| ▸ | TXK | P42681 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14708819 | 0.91 | ITK (0.55) | ITKINSRTXK | |
| SCHEMBL14698953 | 0.83 | ITK (0.65) | ITKINSRTXK | |
| SCHEMBL14708857 | 0.82 | ITK (0.46) | ITKINSR | |
| SCHEMBL6274413 | 0.82 | ITK (0.39) | ITKINSRJAK2JAK1TYK2 | |
| SCHEMBL14708876 | 0.82 | ITK (0.39) | ITKINSR | |
| SCHEMBL21310889 | 0.81 | BACE1 (0.39) | ITKINSR | |
| SCHEMBL6415126 | 0.80 | ITK (0.38) | ITKINSR | |
| SCHEMBL6277070 | 0.80 | ALDH1A1 (0.38) | ITKINSR | |
| SCHEMBL21310819 | 0.79 | TLR8 (0.58) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL14697486 | 0.78 | ITK (0.49) | ITKINSRTXK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013024427-A1 | NOVEL UREA DERIVATIVES AS TEC KINASE INHIBITORS AND USES THEREOF | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-02-21 | — | — | WO | disclosed |