Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 4/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 4/20 | 0.36 |
| ▸ | RET | P07949 | 2/20 | 0.35 |
| ▸ | IRAK1 | P51617 | 3/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
| ▸ | WNT1 | P04628 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14699424 | 0.83 | CYP4F2 (0.40) | IRAK4CYP4F2CYP4A11RETFLT3 | |
| SCHEMBL14689334 | 0.79 | PIM1 (0.49) | — | |
| SCHEMBL15795983 | 0.73 | KDM5B (0.40) | IRAK4CYP4F2CYP4A11FLT3SYK | |
| SCHEMBL14699554 | 0.71 | ATR (0.42) | CYP4F2CYP4A11RETPIK3CDJAK1 | |
| SCHEMBL14688857 | 0.70 | PIM1 (0.51) | — | |
| SCHEMBL30625166 | 0.70 | IRAK4 (0.53) | IRAK4IRAK1CLK2LRRK2GSK3B | |
| SCHEMBL14689981 | 0.69 | SCD (0.39) | IRAK4CYP4F2CYP4A11RETFLT3 | |
| SCHEMBL15795733 | 0.69 | TYRO3 (0.43) | — | |
| SCHEMBL31725423 | 0.68 | RXRA (0.64) | CLK2RXRARXRBRXRGWNT1 | |
| SCHEMBL14688556 | 0.68 | PIM1 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2742046-A1 | PYRAZOLO[3,4-c]PYRIDINE COMPOUNDS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2014-06-18 | — | — | EP | disclosed |
| WO-2013024002-A1 | PYRAZOLO[3,4-c]PYRIDINE COMPOUNDS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2013-02-21 | — | — | WO | disclosed |