Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 2/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 4/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 4/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | PDE8B | O95263 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.36 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14688866 | 0.79 | PIM1 (0.51) | ATRCYP4F2CYP4A11PIM1 | |
| SCHEMBL3433339 | 0.73 | CYP4F2 (0.39) | CYP4F2CYP4A11PIM1MCL1PDE8B | |
| SCHEMBL14699428 | 0.71 | IRAK4 (0.39) | CYP4F2CYP4A11PIK3CDJAK1RET | |
| SCHEMBL13426611 | 0.70 | CD274 (0.48) | CYP4F2CYP4A11PIM1MCL1PDE8B | |
| SCHEMBL116636 | 0.69 | CYP2A6 (0.62) | PIM1KDM4EALDH1A1SMN1; SMN2CYP2A6 | |
| SCHEMBL14688685 | 0.69 | PIM1 (0.41) | ATRCYP4F2CYP4A11PIM1CHRNB2 | |
| SCHEMBL14688512 | 0.69 | PIM1 (0.41) | ATRCYP4F2CYP4A11PIM1MCL1 | |
| SCHEMBL14688800 | 0.69 | CYP4F2 (0.40) | CYP4F2CYP4A11PIM1MCL1 | |
| SCHEMBL18448117 | 0.68 | MCL1 (0.45) | CYP4F2CYP4A11MCL1PDE8BTNF | |
| SCHEMBL14688791 | 0.68 | ATR (0.39) | ATRCYP4F2CYP4A11CHRNB2CHRNA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2742046-A1 | PYRAZOLO[3,4-c]PYRIDINE COMPOUNDS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2014-06-18 | — | — | EP | disclosed |
| WO-2013024002-A1 | PYRAZOLO[3,4-c]PYRIDINE COMPOUNDS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2013-02-21 | — | — | WO | disclosed |