Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.65 |
| ▸ | NPC1 | O15118 | 8/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.65 |
| ▸ | MAPT | P10636 | 10/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14699470 | 1.00 | RAB9A (0.65) | RAB9ANPC1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL14697548 | 0.89 | RAB9A (0.67) | RAB9ANPC1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL14697547 | 0.89 | RAB9A (0.67) | RAB9ANPC1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL14697973 | 0.88 | SMN1; SMN2 (0.65) | RAB9ANPC1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL14698163 | 0.88 | SMN1; SMN2 (0.65) | RAB9ANPC1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL14697529 | 0.88 | RAB9A (0.68) | RAB9ANPC1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL14698159 | 0.88 | RAB9A (0.68) | RAB9ANPC1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL14698025 | 0.79 | MAPT (0.45) | RAB9ANPC1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL14698026 | 0.79 | MAPT (0.45) | RAB9ANPC1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL14709064 | 0.78 | RAB9A (0.76) | RAB9ANPC1SMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9273018-B2 | Piperazine derivatives | ST. MARY'S UNIVERSITY (CA) | 2016-03-01 | — | — | US | claimed |
| US-20140309196-A1 | PIPERAZINE DERIVATIVES | ST. MARY'S UNIVERSITY (CA) | 2014-10-16 | — | — | US | claimed |
| WO-2013023273-A1 | PIPERAZINE DERIVATIVES | ST. MARY'S UNIVERSITY (CA) | 2013-02-21 | — | — | WO | claimed |
| US-9273018-B2 | Piperazine derivatives | ST. MARY'S UNIVERSITY (CA) | 2016-03-01 | — | — | US | disclosed |
| US-20140309196-A1 | PIPERAZINE DERIVATIVES | ST. MARY'S UNIVERSITY (CA) | 2014-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140309196-A1 | PIPERAZINE DERIVATIVES | TP53, EP300, GOT2 | RAB9A 2420/4885NPC1 79/4885SMN1; SMN2 947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.