SCHEMBL3433339

SCHEMBL3433339

O=Cc1cc(-c2cccnc2)nn1C1CCCCO1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP4F2 P78329 3/20 0.39
CYP4A11 Q02928 3/20 0.39
MCL1 Q07820 1/20 0.38
PDE8B O95263 1/20 0.38
TNF P01375 1/20 0.37
CYP2C9 P11712 4/20 0.36
CYP2C19 P33261 4/20 0.36
CYP3A4 P08684 4/20 0.36
CYP2E1 P05181 3/20 0.36
CYP2B6 P20813 3/20 0.36
CYP2A6 P11509 2/20 0.36
ALDH1A1 P00352 3/20 0.36
ACHE P22303 1/20 0.36
KDM4E B2RXH2 1/20 0.36
CYP2D6 P10635 2/20 0.36
CHRM2 P08172 1/20 0.36
CHRM4 P08173 1/20 0.36
CHRM5 P08912 1/20 0.36
CHRM1 P11229 1/20 0.36
CHRM3 P20309 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3433705 0.88 CNR1 (0.38) CYP4F2CYP4A11MCL1ALDH1A1
SCHEMBL13425995 0.87 CYP4F2 (0.38) CYP4F2CYP4A11ALDH1A1PIM1ACVRL1
SCHEMBL13425986 0.80 CYP4F2 (0.37) CYP4F2CYP4A11ALDH1A1KDM4ECHRM2
SCHEMBL13425989 0.78 ALDH1A1 (0.39) CYP4F2CYP4A11TNFALDH1A1KDM4E
SCHEMBL12886311 0.76 MCL1 (0.40) MCL1
SCHEMBL13426611 0.76 CD274 (0.48) CYP4F2CYP4A11MCL1PDE8BTNF
SCHEMBL15365137 0.76 CYP4F2 (0.37) CYP4F2CYP4A11MCL1PDE8BTNF
SCHEMBL25187212 0.75 CYP4F2 (0.34) CYP4F2CYP4A11TNFACVRL1ACVR1
SCHEMBL20389670 0.74 ALDH1A1 (0.38) CYP4F2CYP4A11CYP2C19ALDH1A1
SCHEMBL14699554 0.73 ATR (0.42) CYP4F2CYP4A11MCL1PDE8BTNF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010046780-A2 ANTI VIRAL COMPOUNDS INSTITUT PASTEUR KOREA (KR) 2010-04-29 WO disclosed
WO-2010046780-A2 ANTI VIRAL COMPOUNDS INSTITUT PASTEUR KOREA (KR) 2010-04-29 WO disclosed