Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 3/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | F10 | P00742 | 4/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.33 |
| ▸ | ACVRL1 | P37023 | 4/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14312774 | 0.82 | PIK3CA (0.47) | PIK3CDPIK3CAACVRL1 | |
| SCHEMBL58590 | 0.81 | FGFR1 (0.43) | ACVRL1FGFR1FGFR3 | |
| SCHEMBL5077251 | 0.76 | ACVRL1 (0.38) | PIK3CAACVRL1 | |
| SCHEMBL5076918 | 0.75 | ACVRL1 (0.54) | ACVRL1FGFR1FGFR3 | |
| SCHEMBL59827 | 0.75 | ACVRL1 (0.54) | PIK3CDPIK3CAACVRL1 | |
| SCHEMBL16011367 | 0.73 | ACVRL1 (0.51) | PIK3CDACVRL1FGFR1FGFR3 | |
| SCHEMBL5081034 | 0.72 | PDE1B (0.41) | PIK3CDACVRL1 | |
| SCHEMBL16011362 | 0.71 | ACVRL1 (0.53) | PIK3CDTLR7ACVRL1FGFR1FGFR3 | |
| SCHEMBL59450 | 0.71 | ACVRL1 (0.50) | PIK3CDPIK3CAACVRL1FGFR1 | |
| SCHEMBL65554 | 0.70 | MAP4K4 (0.41) | ADORA2ASLC2A1TNIKACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957485-B1 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | BAYER HEALTHCARE LLC (US) | 2013-02-13 | — | — | EP | disclosed |