SCHEMBL14701278

SCHEMBL14701278

C=CC(=O)OCc1ccc(C(C)(O)C(F)(F)F)c2ccccc12

nearest known ligand 0.35

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
THRB P10828 2/20 0.35
KCNJ11 Q14654 11/20 0.35
ABCC9 O60706 6/20 0.35
ABCC8 Q09428 6/20 0.35
KCNJ8 Q15842 6/20 0.35
ACE2 Q9BYF1 1/20 0.32
MAPK1 P28482 1/20 0.31
THRA P10827 1/20 0.31
HSD11B1 P28845 1/20 0.31
NR3C1 P04150 1/20 0.31
PGR P06401 1/20 0.31
NR3C2 P08235 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14701285 0.87 ACE2 (0.42) THRBACE2MAPK1THRA
SCHEMBL12242602 0.81 THRB (0.38) THRB
SCHEMBL7236743 0.79 THRB (0.44) THRBTHRA
SCHEMBL14701272 0.78 THRB (0.37) THRBKCNJ11ABCC9ABCC8KCNJ8
SCHEMBL27421526 0.75 THRB (0.45) THRBMAPK1THRA
SCHEMBL12213820 0.75 PPARD (0.33) THRBNR3C1PGRNR3C2
SCHEMBL24609573 0.74 THRB (0.43) THRB
SCHEMBL10033659 0.73 EP300 (0.41) THRBTHRA
SCHEMBL12332753 0.72 THRB (0.44) THRBTHRA
SCHEMBL10887726 0.72 IDO1 (0.51) THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9040225-B2 Developable bottom antireflective coating composition and pattern forming method using thereof INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2015-05-26 US disclosed
US-8715907-B2 Developable bottom antireflective coating compositions for negative resists INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2014-05-06 US disclosed
US-20130040238-A1 DEVELOPABLE BOTTOM ANTIREFLECTIVE COATING COMPOSITIONS FOR NEGATIVE RESISTS INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2013-02-14 US disclosed