Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.59 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15062403 | 1.00 | ACE2 (0.59) | ACE2GABRR1CYP1A2BLMLTA4H | |
| SCHEMBL18159069 | 0.93 | ACE2 (0.53) | ACE2GABRR1CYP1A2BLMLTA4H | |
| SCHEMBL5739604 | 0.88 | BLM (0.69) | ACE2GABRR1CYP1A2BLMLTA4H | |
| SCHEMBL592495 | 0.86 | ACE2 (0.68) | ACE2GABRR1CYP1A2BLMLTA4H | |
| SCHEMBL6293897 | 0.86 | ACE2 (0.68) | ACE2GABRR1CYP1A2BLMLTA4H | |
| SCHEMBL16431036 | 0.86 | ACE2 (0.68) | ACE2GABRR1CYP1A2BLMLTA4H | |
| SCHEMBL231310 | 0.86 | ACE2 (0.68) | ACE2GABRR1CYP1A2BLMLTA4H | |
| SCHEMBL3302699 | 0.86 | BLM (0.73) | ACE2GABRR1CYP1A2BLMLTA4H | |
| SCHEMBL21541575 | 0.86 | ACE2 (0.68) | ACE2GABRR1CYP1A2BLMLTA4H | |
| SCHEMBL5879059 | 0.86 | ACE2 (0.68) | ACE2GABRR1CYP1A2BLMLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160002286-A1 | CHEMICAL PREPARATION OF UBIQUITIN THIOESTERS AND MODIFICATIONS THEREOF | BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY | 2016-01-07 | — | — | US | disclosed |
| US-9175053-B2 | Chemical preparation of ubiquitin thioesters and modifications thereof | BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY (IL) | 2015-11-03 | — | — | US | disclosed |
| US-9079966-B2 | Chemical preparation of polyubiquitin chains | BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY (IL) | 2015-07-14 | — | — | US | disclosed |
| US-20130060003-A1 | CHEMICAL PREPARATION OF POLYUBIQUITIN CHAINS | BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY (IL) | 2013-03-07 | — | — | US | disclosed |
| US-20130041132-A1 | CHEMICAL PREPARATION OF UBIQUITIN THIOESTERS AND MODIFICATIONS THEREOF | BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY (IL) | 2013-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130060003-A1 | CHEMICAL PREPARATION OF POLYUBIQUITIN CHAINS | UBQLN1, UBE3A, UBQLN2 | ACE2 3613/4885GABRR1 986/4885CYP1A2 3293/4885 |
| US-20160002286-A1 | CHEMICAL PREPARATION OF UBIQUITIN THIOESTERS AND MODIFICATIONS THEREOF | OTUB1, USP28, PTMS | ACE2 3034/4885GABRR1 4012/4885CYP1A2 4077/4885 |
| US-20130041132-A1 | CHEMICAL PREPARATION OF UBIQUITIN THIOESTERS AND MODIFICATIONS THEREOF | OTUB1, USP28, PTMS | ACE2 3034/4885GABRR1 4012/4885CYP1A2 4077/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.