Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.33 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | TSHR | P16473 | 5/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | CA3 | P07451 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL31057639 | 0.96 | ALDH1A1 (0.35) | ALDH1A1TSHRTDP1ALOX12CA1 | |
| SCHEMBL26674 | 0.96 | ALDH1A1 (0.40) | ALDH1A1TSHRTDP1ALOX12CA1 | |
| Benzene SCHEMBL28207368 | 0.96 | ALDH1A1 (0.40) | ALDH1A1TSHRTDP1ALOX12CA1 | |
| SCHEMBL28748541 | 0.96 | ALDH1A1 (0.40) | ALDH1A1TSHRTDP1ALOX12CA1 | |
| Fluoride SCHEMBL3304552 | 0.92 | ALDH1A1 (0.38) | ALDH1A1TSHRTDP1ALOX12CA1 | |
| SCHEMBL9068833 | 0.92 | ALDH1A1 (0.38) | ALDH1A1TSHRTDP1ALOX12CA1 | |
| Iodide SCHEMBL8800806 | 0.92 | ALDH1A1 (0.38) | ALDH1A1TSHRTDP1ALOX12CA1 | |
| Phosphine SCHEMBL20701190 | 0.92 | ALDH1A1 (0.38) | ALDH1A1TSHRTDP1ALOX12CA1 | |
| Water SCHEMBL18039121 | 0.92 | ALDH1A1 (0.38) | ALDH1A1TSHRTDP1ALOX12CA1 | |
| SCHEMBL9064400 | 0.92 | ALDH1A1 (0.38) | ALDH1A1TSHRTDP1ALOX12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 288 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122010959-A | Novel synthesis method of treasipril | 上海上药第一生化药业有限公司 | 2026-05-12 | — | — | CN | claimed |
| CN-122010951-A | New preparation method of reboxetine | 上海上药第一生化药业有限公司 | 2026-05-12 | — | — | CN | claimed |
| CN-116003744-B | Method for preparing phosphorus-containing polymer by proton acid catalytic Friedel-crafts polymerization | 中国科学院兰州化学物理研究所 | 2025-06-10 | — | — | CN | claimed |
| CN-120081743-A | Synthesis method of fluxapyroxad intermediate trifluoro-nitrobiphenyl | 辽宁众辉生物科技有限公司 | 2025-06-03 | — | — | CN | claimed |
| CN-120058494-A | Preparation method of aromatic carbonyl compound | 哈尔滨理工大学 | 2025-05-30 | — | — | CN | claimed |
| CN-119978318-A | Phosphorus-containing latent accelerator, epoxy composition, preparation method and application thereof | 广州立能新材料有限公司 | 2025-05-13 | — | — | CN | claimed |
| CN-116020568-B | Cycloaddition catalyst, preparation method and application thereof and CO2Method for preparing cyclic carbonate by cycloaddition with epoxide | 中国石油化工股份有限公司 | 2025-04-25 | — | — | CN | claimed |
| CN-119799229-A | Epoxy plastic package material and preparation method and application thereof | 江苏中科科化新材料股份有限公司 | 2025-04-11 | — | — | CN | claimed |
| CN-119702086-A | Preparation method of eggshell type catalyst, obtained catalyst, device used by catalyst and application of catalyst | 相流(北京)科技有限公司 | 2025-03-28 | — | — | CN | claimed |
| CN-116143628-B | Preparation method of nitrobenzamide | 南通泰禾化工股份有限公司 | 2025-03-25 | — | — | CN | claimed |
| CN-113200842-A | Adipic acid preparation method and system | 中石油吉林化工工程有限公司 | 2021-08-03 | — | — | CN | claimed |
| CN-112357876-A | Method for preparing polymer array by combining 3D printing with electric field induced molding | 四川大学 | 2021-02-12 | — | — | CN | claimed |
| CN-108191628-B | Method for preparing bis- (heptafluoroisopropyl) -ketone by oxalyl chloride fluorination | 武汉大学 | 2020-07-24 | — | — | CN | claimed |
| CN-107803222-B | Ruthenium complex catalyst for acetylene hydrochlorination | 浙江工业大学 | 2020-06-09 | — | — | CN | claimed |
| CN-110788345-A | Size-controllable Pt1Ag28Synthesis method of alloy nanocluster | 中国科学院大连化学物理研究所 | 2020-02-14 | — | — | CN | claimed |
| US-9522915-B2 | Method for preparing an important intermediate of linagliptin | 2Y-CHEM, LTD. (CN) | 2016-12-20 | — | — | US | claimed |
| US-20160068506-A1 | COMBRETASTATIN ANALOGS | BIOVENTURES, LLC | 2016-03-10 | — | — | US | claimed |
| EP-2986596-A2 | COMBRETASTATIN ANALOGS | The Board of Trustees of the University of Arkansas (US) | 2016-02-24 | — | — | EP | claimed |
| US-20150274728-A1 | METHOD FOR PREPARING AN IMPORTANT INTERMEDIATE OF LINAGLIPTIN | 2Y-CHEM, LTD. (CN) | 2015-10-01 | — | — | US | claimed |
| WO-2014172363-A2 | COMBRETASTATIN ANALOGS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (US) | 2014-10-23 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150274728-A1 | METHOD FOR PREPARING AN IMPORTANT INTERMEDIATE OF LINAGLIPTIN | DPP4, DPP9, DPP3 | ACHE 133/4885SLC6A2 3405/4885ALDH1A1 223/4885 |
| US-20160068506-A1 | COMBRETASTATIN ANALOGS | HDAC6, HDAC11, HDAC5 | ACHE 4710/4885SLC6A2 4695/4885ALDH1A1 2977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.