Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.46 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ESR1 | P03372 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | GMNN | O75496 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24126966 | 0.87 | SMN1; SMN2 (0.53) | KDM4EALDH1A1MEN1KMT2APOLB | |
| SCHEMBL108090 | 0.80 | CA1 (0.54) | KDM4EALDH1A1ERCC1ERCC4ALOX15 | |
| SCHEMBL19222138 | 0.79 | POLB (0.56) | KDM4EALDH1A1MEN1KMT2APOLB | |
| SCHEMBL14543288 | 0.79 | ERCC1 (0.49) | KDM4EALDH1A1ERCC1ERCC4ALOX15 | |
| SCHEMBL19075637 | 0.79 | SMN1; SMN2 (0.59) | KDM4EALDH1A1MEN1KMT2APOLB | |
| SCHEMBL7379184 | 0.77 | HRH3 (0.59) | KDM4EALDH1A1ERCC1ERCC4POLB | |
| SCHEMBL3259492 | 0.76 | LMNA (0.57) | ALDH1A1LMNAACHE | |
| SCHEMBL7952371 | 0.76 | ACHE (0.66) | KDM4EALDH1A1MEN1KMT2APOLB | |
| SCHEMBL12658239 | 0.76 | LMNA (0.56) | KDM4EALDH1A1POLBLMNAHSP90AA1 | |
| SCHEMBL25531010 | 0.75 | TEAD1 (0.52) | KDM4EALDH1A1MEN1KMT2ANR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013024895-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS AND JAK INHIBITORS | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2013-02-21 | — | — | WO | disclosed |