Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | MERTK | Q12866 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GSR | P00390 | 3/20 | 0.40 |
| ▸ | TXNRD1 | Q16881 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30889027 | 0.89 | ALDH1A1 (0.48) | ALDH1A1MAPTMERTKHTTL3MBTL1 | |
| SCHEMBL6642983 | 0.89 | ALDH1A1 (0.48) | ALDH1A1MAPTMERTKHTTL3MBTL1 | |
| SCHEMBL30937582 | 0.83 | ALDH1A1 (0.60) | ALDH1A1MAPTHTTGSRTXNRD1 | |
| SCHEMBL11827515 | 0.82 | ALDH1A1 (0.47) | ALDH1A1MAPTMERTKHTTL3MBTL1 | |
| SCHEMBL3961361 | 0.81 | KMT2A (0.44) | ALDH1A1MAPTMERTKHTTL3MBTL1 | |
| SCHEMBL13586870 | 0.80 | MAPT (0.46) | ALDH1A1MAPTMERTKHTTL3MBTL1 | |
| SCHEMBL11010423 | 0.78 | MAPT (0.42) | ALDH1A1MAPTMERTKHTTL3MBTL1 | |
| SCHEMBL10696959 | 0.77 | MAPT (0.55) | ALDH1A1MAPTMERTKHTTL3MBTL1 | |
| SCHEMBL9110706 | 0.77 | MAPT (0.65) | ALDH1A1MAPTMERTKHTTL3MBTL1 | |
| SCHEMBL8313767 | 0.77 | MAPT (0.65) | ALDH1A1MAPTMERTKHTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8975235-B2 | Lysophosphatidic acid receptor antagonists | INTERMUNE, INC. (US) | 2015-03-10 | — | — | US | disclosed |
| US-8975235-B2 | Lysophosphatidic acid receptor antagonists | INTERMUNE, INC. (US) | 2015-03-10 | — | — | US | disclosed |
| US-20130072449-A1 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | INTERMUNE, INC. (US) | 2013-03-21 | — | — | US | disclosed |
| US-20130072449-A1 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | INTERMUNE, INC. (US) | 2013-03-21 | — | — | US | disclosed |
| WO-2013025733-A1 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | INTERMUNE, INC. (US) | 2013-02-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130072449-A1 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | LPAR1, LPAR2, LPAR5 | ALDH1A1 4135/4885MAPT 4564/4885MERTK 1831/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.