Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 8/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | GSR | P00390 | 1/20 | 0.39 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.39 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.39 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30889027 | 0.92 | ALDH1A1 (0.48) | KMT2ALMNAALDH1A1MAPTHTT | |
| SCHEMBL6642983 | 0.92 | ALDH1A1 (0.48) | KMT2ALMNAALDH1A1MAPTHTT | |
| SCHEMBL24496404 | 0.88 | ALDH1A1 (0.43) | KMT2ALMNAALDH1A1MAPTGSTP1 | |
| SCHEMBL29392101 | 0.85 | TXNRD1 (0.44) | KMT2ALMNAALDH1A1MAPTGSR | |
| SCHEMBL24251666 | 0.85 | TXNRD1 (0.44) | KMT2ALMNAALDH1A1MAPTGSR | |
| SCHEMBL3968921 | 0.83 | ALDH1A1 (0.39) | KMT2ALMNAALDH1A1MAPTL3MBTL1 | |
| SCHEMBL13040072 | 0.83 | LMNA (0.50) | KMT2ALMNAALDH1A1MAPTHTT | |
| SCHEMBL14710607 | 0.81 | ALDH1A1 (0.60) | KMT2AALDH1A1MAPTHTTGSR | |
| SCHEMBL13586870 | 0.81 | MAPT (0.46) | KMT2ALMNAALDH1A1MAPTHTT | |
| SCHEMBL24496548 | 0.81 | ALDH1A1 (0.67) | KMT2ALMNAALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7626031-B2 | 5-[(1-Ethylpiperidin-4-yl)amino]-3-[(3-fluorophenyl)(1H-imidazol-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one; antiproliferative agents; modulating cell differentiation,migration, and chemoinvasion; endothelial growth factor-modulated diseases; antiarthritic agents; graft versus host diseases | SYMPHONY EVOLUTION, INC. (US) | 2009-12-01 | — | — | US | disclosed |
| EP-1581309-A4 | KINASE MODULATORS | EXELIXIS INC (US) | 2009-07-29 | — | — | EP | disclosed |
| US-20060122171-A1 | Kinase modulators | SYMPHONY EVOLUTION, INC. | 2006-06-08 | — | — | US | disclosed |
| EP-1581309-A2 | KINASE MODULATORS | Exelixis, Inc. (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004050681-A2 | KINASE MODULATORS | EXELIXIS, INC. (US) | 2004-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122171-A1 | Kinase modulators | FLT1, KDR, FLT4 | KMT2A 3778/4885LMNA 3325/4885ALDH1A1 1525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.