SCHEMBL1471075

SCHEMBL1471075

COC(=O)C(NC(C)=O)C(=O)OC

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.42
ALDH1A1 P00352 3/20 0.40
CA14 Q9ULX7 2/20 0.36
KDM4E B2RXH2 2/20 0.34
MAPT P10636 1/20 0.34
THRB P10828 1/20 0.34
ALOX15 P16050 1/20 0.34
NFKB1 P19838 1/20 0.34
PTGS2 P35354 1/20 0.34
THPO P40225 1/20 0.34
RECQL P46063 1/20 0.34
BLM P54132 1/20 0.34
LMNA P02545 1/20 0.34
CA2 P00918 3/20 0.33
CA12 O43570 2/20 0.33
KMT2A Q03164 2/20 0.33
CA1 P00915 2/20 0.33
PTGS1 P23219 1/20 0.33
MMP12 P39900 1/20 0.33
CA9 Q16790 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4961544 0.90 SMN1; SMN2 (0.39) SMN1; SMN2ALDH1A1CA14KDM4EMAPT
SCHEMBL6986221 0.87 SMN1; SMN2 (0.40) SMN1; SMN2ALDH1A1CA14KDM4EMAPT
SCHEMBL17483032 0.87 SMN1; SMN2 (0.40) SMN1; SMN2ALDH1A1CA14KDM4EMAPT
SCHEMBL16727820 0.87 LMNA (0.49) ALDH1A1KDM4EMAPTTHRBALOX15
SCHEMBL7947980 0.85 SMN1; SMN2 (0.38) SMN1; SMN2ALDH1A1CA14KDM4EMAPT
SCHEMBL11879871 0.82 LMNA (0.33) SMN1; SMN2LMNA
SCHEMBL11874497 0.82 LMNA (0.33) SMN1; SMN2LMNA
SCHEMBL23052110 0.80 LMNA (0.35) SMN1; SMN2ALDH1A1CA14LMNACA12
SCHEMBL9432505 0.80 TSHR (0.34) SMN1; SMN2ALDH1A1
SCHEMBL12275519 0.80 MGAM (0.43) SMN1; SMN2ALDH1A1KDM4EMAPTTHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11667658-B2 Chemical synthesis of the organoarsenical antibiotic arsinothricin THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) 2023-06-06 US claimed
US-20230093812-A1 CHEMICAL SYNTHESIS OF THE ORGANOARSENICAL ANTIBIOTIC ARSINOTHRICIN THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) 2023-03-30 US claimed
CN-115703776-B Plasmin inhibitor, preparation method and application thereof 赛诺哈勃药业(成都)有限公司 2025-06-17 CN disclosed
US-20240300986-A1 PLASMIN INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF SCINNOHUB PHARMACEUTICAL CO., LTD (CN) 2024-09-12 US disclosed
US-20240124443-A1 PLASMIN INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF SCINNOHUB PHARMACEUTICAL CO., LTD (CN) 2024-04-18 US disclosed
EP-4289850-A1 PLASMIN INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF Scinnohub Pharmaceutical Co., Ltd (CN) 2023-12-13 EP disclosed
EP-4289850-A1 PLASMIN INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF Scinnohub Pharmaceutical Co., Ltd (CN) 2023-12-13 EP disclosed
EP-4273135-A1 PLASMIN INHIBITOR, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF Scinnohub Pharmaceutical Co., Ltd (CN) 2023-11-08 EP disclosed
CN-116848122-A Plasmin inhibitor, preparation method and application thereof 赛诺哈勃药业(成都)有限公司 2023-10-03 CN disclosed
CN-116710440-A Plasmin inhibitor, preparation method and application thereof 赛诺哈勃药业(成都)有限公司 2023-09-05 CN disclosed
US-11667658-B2 Chemical synthesis of the organoarsenical antibiotic arsinothricin THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) 2023-06-06 US disclosed
EP-0726896-A1 5-ARYLISOXAZOL-4-YL-SUBSTITUTED 2-AMINO CARBOXYLIC ACID COMPOUNDS H. LUNDBECK A/S (DK) 1996-08-21 EP disclosed
WO-1995012587-A1 5-ARYLISOXAZOL-4-YL-SUBSTITUTED 2-AMINO CARBOXYLIC ACID COMPOUNDS H. LUNDBECK A/S (DK) 1995-05-11 WO disclosed
EP-0627406-A1 2-AMINO-1,3-PROPANEDIOL COMPOUND AND IMMUNOSUPPRESSANT YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1994-12-07 EP disclosed
US-5045540-A Amide or urea compounds containing imidazole groups WARNER-LAMBERT CO. (US) 1991-09-03 US disclosed
US-5041552-A Treatment of hypertension, heart failure, glaucoma and hyperaldosteronism WARNER-LAMBERT COMPANY (US) 1991-08-20 US disclosed
US-4739049-A Phosphorylation of cyclic amides HOFFMANN-LA ROCHE INC. (US) 1988-04-19 US disclosed
US-4465844-A PEPTIDE, GERMICIDE, DISINFECTANT TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1984-08-14 US disclosed
US-4436918-A FROM A 2,5-DIOXOPYRROLIDINE COMPOUND TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1984-03-13 US disclosed
US-4084057-A Process for the production of 4-acylamido-4, 4-dicarbalkoxy-butanalphenylhydrazone DEUTSCHE GOLD- UND SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DT) 1978-04-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240124443-A1 PLASMIN INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF F2, PLG, PLAT SMN1; SMN2 4574/4885ALDH1A1 699/4885CA14 1266/4885
US-20240300986-A1 PLASMIN INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF F2, PLG, PLAT SMN1; SMN2 4535/4885ALDH1A1 1044/4885CA14 2264/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.