Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MME | P08473 | 2/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.32 |
| ▸ | CA12 | O43570 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17483032 | 1.00 | SMN1; SMN2 (0.40) | SMN1; SMN2KDM4EMAPTTHRBALOX15 | |
| SCHEMBL1471075 | 0.87 | SMN1; SMN2 (0.42) | SMN1; SMN2KDM4EMAPTTHRBALOX15 | |
| SCHEMBL4961544 | 0.83 | SMN1; SMN2 (0.39) | SMN1; SMN2KDM4EMAPTTHRBALOX15 | |
| SCHEMBL11487898 | 0.82 | KDM4E (0.38) | SMN1; SMN2KDM4EMAPTTHRBALOX15 | |
| SCHEMBL143910 | 0.82 | KDM4E (0.48) | SMN1; SMN2KDM4EMAPTTHRBALOX15 | |
| SCHEMBL6261013 | 0.80 | KDM4E (0.36) | SMN1; SMN2KDM4EMAPTTHRBALOX15 | |
| SCHEMBL706882 | 0.80 | LMNA (0.49) | SMN1; SMN2KDM4EMAPTTHRBALOX15 | |
| SCHEMBL9614381 | 0.79 | KDM4E (0.46) | SMN1; SMN2KDM4EMAPTTHRBALOX15 | |
| SCHEMBL7947980 | 0.79 | SMN1; SMN2 (0.38) | SMN1; SMN2KDM4EMAPTTHRBALOX15 | |
| SCHEMBL28073505 | 0.79 | KMT2A (0.36) | SMN1; SMN2KDM4EMAPTTHRBALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268422-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | Bayer Aktiengesellschaft (DE) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070687-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-09-27 | — | — | WO | disclosed |