Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14790527 | 0.88 | POLB (0.49) | POLBNPC1RAB9AP2RX7SMN1; SMN2 | |
| SCHEMBL14711284 | 0.80 | LPAR1 (0.48) | POLBROCK2MGLL | |
| SCHEMBL14790528 | 0.79 | ROCK2 (0.42) | POLBNPC1RAB9AP2RX7SMN1; SMN2 | |
| SCHEMBL14711391 | 0.78 | LPAR1 (0.42) | POLBNPC1RAB9ASMN1; SMN2ROCK2 | |
| SCHEMBL12772987 | 0.69 | NPC1 (0.58) | POLBNPC1RAB9ASMN1; SMN2MGLL | |
| SCHEMBL16040355 | 0.68 | NPC1 (0.51) | POLBNPC1RAB9ASMN1; SMN2ROCK2 | |
| SCHEMBL19993034 | 0.68 | POLB (0.70) | POLBNPC1RAB9AP2RX7SMN1; SMN2 | |
| SCHEMBL18109145 | 0.68 | RAB9A (0.60) | POLBRAB9ASMN1; SMN2ROCK2TP53 | |
| SCHEMBL6557730 | 0.67 | NPC1 (0.49) | POLBNPC1RAB9AP2RX7SMN1; SMN2 | |
| Benzyl Phenylcarbamate SCHEMBL1222943 | 0.67 | POLB (0.78) | POLBNPC1RAB9ASMN1; SMN2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013025733-A1 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | INTERMUNE, INC. (US) | 2013-02-21 | — | — | WO | disclosed |