Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 3/20 | 0.41 |
| ▸ | REN | P00797 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1470808 | 0.82 | HDAC3 (0.47) | HDAC1HDAC3HDAC2NCOR2L3MBTL1 | |
| SCHEMBL1471034 | 0.82 | HDAC3 (0.47) | HDAC1HDAC3HDAC2NCOR2CTSL | |
| SCHEMBL19057816 | 0.82 | METAP2 (0.44) | HDAC1HDAC3HDAC2NCOR2KDM1A | |
| SCHEMBL1470951 | 0.81 | KDM4E (0.46) | HDAC1HDAC3HDAC2NCOR2CTSL | |
| SCHEMBL1470736 | 0.81 | NPC1 (0.41) | HDAC1RECQL | |
| SCHEMBL7206187 | 0.79 | HDAC3 (0.55) | HDAC1HDAC3HDAC2NCOR2CTSL | |
| SCHEMBL1231760 | 0.79 | HDAC3 (0.53) | HDAC1HDAC3HDAC2NCOR2CTSL | |
| SCHEMBL4147838 | 0.79 | HDAC1 (0.56) | HDAC1HDAC3HDAC2NCOR2CTSL | |
| SCHEMBL8619045 | 0.78 | HDAC1 (0.54) | HDAC1HDAC3HDAC2NCOR2CTSL | |
| SCHEMBL19493163 | 0.77 | HDAC1 (0.48) | HDAC1HDAC3HDAC2NCOR2CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7915420-B2 | Aryl piperidine amides | JANSSEN PHARMACEUTICA NV (BE) | 2011-03-29 | — | — | US | disclosed |
| US-20080009521-A1 | Aryl Piperidine Amides | HUANG CHARLES Q | 2008-01-10 | — | — | US | disclosed |
| US-7276610-B2 | Aryl piperidine amides | JANSSEN PHARACEUTICA, NV (BE) | 2007-10-02 | — | — | US | disclosed |
| US-20050049239-A1 | Aryl piperidine amides | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080009521-A1 | Aryl Piperidine Amides | BDNF, NTRK2, OPRL1 | HDAC1 354/4885HDAC3 127/4885HDAC2 283/4885 |
| US-20050049239-A1 | Aryl piperidine amides | BDNF, NTRK2, OPRL1 | HDAC1 354/4885HDAC3 127/4885HDAC2 283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.