Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 17/20 | 1.00 |
| ▸ | CES1 | P23141 | 7/20 | 1.00 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.79 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14273017 | 0.89 | FAAH (0.81) | FAAHCES1DAGLANCEH1 | |
| SCHEMBL3144399 | 0.89 | FAAH (1.00) | FAAHCES1DAGLANCEH1 | |
| SCHEMBL3134547 | 0.89 | FAAH (1.00) | FAAHCES1DAGLANCEH1 | |
| SCHEMBL3145505 | 0.89 | FAAH (1.00) | FAAHCES1DAGLANCEH1 | |
| SCHEMBL3134352 | 0.86 | FAAH (1.00) | FAAHCES1DAGLANCEH1 | |
| SCHEMBL3140826 | 0.86 | FAAH (1.00) | FAAHCES1DAGLA | |
| SCHEMBL3136157 | 0.86 | FAAH (1.00) | FAAHCES1DAGLANCEH1 | |
| SCHEMBL3130534 | 0.85 | FAAH (1.00) | FAAHCES1DAGLANCEH1 | |
| SCHEMBL3145274 | 0.85 | FAAH (1.00) | FAAHCES1DAGLANCEH1 | |
| SCHEMBL3148633 | 0.85 | FAAH (1.00) | FAAHCES1NCEH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268817-B2 | Substituted oxazole ketone modulators of fatty acid amide hydrolase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2012-09-18 | — | — | US | claimed |
| US-20100075931-A1 | Substituted oxazole ketone modulators of fatty acid amide hydrolase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-03-25 | — | — | US | claimed |
| EP-2068862-A2 | SUBSTITUTED OXAZOLE KETONE MODULATORS OF FATTY ACID AMIDE HYDROLASE | The Scripps Research Institute (US) | 2009-06-17 | — | — | EP | claimed |
| WO-2008030532-A2 | SUBSTITUTED OXAZOLE KETONE MODULATORS OF FATTY ACID AMIDE HYDROLASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-03-13 | — | — | WO | claimed |
| EP-1983994-B1 | OXAZOLE KETONES AS MODULATORS OF FATTY ACID AMIDE HYDROLASE | SCRIPPS RESEARCH INST (US) | 2015-09-30 | — | — | EP | disclosed |
| US-8268817-B2 | Substituted oxazole ketone modulators of fatty acid amide hydrolase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2012-09-18 | — | — | US | disclosed |
| US-8268817-B2 | Substituted oxazole ketone modulators of fatty acid amide hydrolase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2012-09-18 | — | — | US | disclosed |
| US-8268817-B2 | Substituted oxazole ketone modulators of fatty acid amide hydrolase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2012-09-18 | — | — | US | disclosed |
| US-7915270-B2 | Oxazole ketones as modulators of fatty acid amide hydrolase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-03-29 | — | — | US | disclosed |
| US-20100075931-A1 | Substituted oxazole ketone modulators of fatty acid amide hydrolase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-03-25 | — | — | US | disclosed |
| US-20100075931-A1 | Substituted oxazole ketone modulators of fatty acid amide hydrolase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-03-25 | — | — | US | disclosed |
| US-20100075931-A1 | Substituted oxazole ketone modulators of fatty acid amide hydrolase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-03-25 | — | — | US | disclosed |
| EP-2068862-A2 | SUBSTITUTED OXAZOLE KETONE MODULATORS OF FATTY ACID AMIDE HYDROLASE | The Scripps Research Institute (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-1983994-A2 | OXAZOLE KETONES AS MODULATORS OF FATTY ACID AMIDE HYDROLASE | The Scripps Research Institute (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2008030532-A2 | SUBSTITUTED OXAZOLE KETONE MODULATORS OF FATTY ACID AMIDE HYDROLASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-03-13 | — | — | WO | disclosed |
| WO-2008030532-A2 | SUBSTITUTED OXAZOLE KETONE MODULATORS OF FATTY ACID AMIDE HYDROLASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-03-13 | — | — | WO | disclosed |
| WO-2007098142-A2 | OXAZOLE KETONES AS MODULATORS OF FATTY ACID AMIDE HYDROLASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-08-30 | — | — | WO | disclosed |
| US-20070203156-A1 | Oxazole ketones as modulators of fatty acid amide hydrolase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075931-A1 | Substituted oxazole ketone modulators of fatty acid amide hydrolase | FAAH, FAAH2, HCRTR2 | FAAH 1/4885CES1 94/4885DAGLA 792/4885 |
| US-20070203156-A1 | Oxazole ketones as modulators of fatty acid amide hydrolase | FAAH, FAAH2, HCRTR2 | FAAH 1/4885CES1 81/4885DAGLA 530/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.