FAAH2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Urb-597 (SCHEMBL93842)	1.00	1/20
SCHEMBL1471932	1.00	1/20
SCHEMBL3183288	1.00	1/20
SCHEMBL3193713	1.00	1/20
SCHEMBL3203964	1.00	1/20
Urb-597 (SCHEMBL29371698)	1.00	1/20
SCHEMBL3196450	0.98	1/20
SCHEMBL14187855	0.98	1/20
SCHEMBL17175654	0.93	1/20
SCHEMBL3184217	0.91	1/20
SCHEMBL4750537	0.86	1/20
SCHEMBL712398	0.85	1/20
SCHEMBL10089400	0.84	1/20
SCHEMBL710090	0.83	1/20
SCHEMBL710091	0.83	1/20
SCHEMBL710374	0.83	1/20
SCHEMBL710756	0.83	1/20
SCHEMBL719614	0.83	1/20
SCHEMBL720053	0.83	1/20
SCHEMBL14188106	0.82	1/20

Clinical trials — most relevant to FAAH2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Investigating the Effects of Nabilone on Endocannabinoid Metabolism	PHASE4	COMPLETED
Treatment Strategies in CHS	PHASE4	COMPLETED
Efficacy of Ultra-micronized Palmitoylethanolamide (Um-PEA) in Geriatric Patients With Chronic Pain	PHASE4	COMPLETED
European Celecoxib Trial in Primary Breast Cancer	PHASE3	COMPLETED
Effect of Cannabinoid Agonist on Gastrointestinal and Colonic Motor Functions in Patients With Irritable Bowel Syndrome (IBS)	PHASE2	COMPLETED
Safety and Efficacy Study of PEA and Polydatin on Intestinal Inflammation and Visceral Hyperalgesia in IBS Patients	PHASE2	UNKNOWN
Analgesic Efficacy of Pre-Operative Dose of Palmitoylethanolamide in Patients Undergoing Total Knee Arthroplasty	PHASE1/PHASE2	NOT_YET_RECRUITING
Safety and Efficacy of a FAAH-Inhibitor to Treat Cannabis Withdrawal	PHASE2	COMPLETED
Palmitoylethanolamide for Chronic Inflammatory Pain Conditions	PHASE2	RECRUITING
Effect of Hemp-CBD on Patients With CIPN	PHASE2	UNKNOWN
Ibuprofen Versus Acetaminophen for Treatment of Mild Traumatic Brain Injury	PHASE2	WITHDRAWN
A Study Investigating the Bioavailability of CBD and THC in an Emulsion Product in a Healthy Population	PHASE1	COMPLETED
Safety, Tolerability, and Pharmacokinetics of Multiple Doses of Oral EC5026 in Healthy Subjects	PHASE1	COMPLETED
Topical Cannabidiol Cream and Post-exercise Recovery	EARLY_PHASE1	WITHDRAWN
Gene Expression of Endocannabinoid System in Episodic and Chronic Migraine Patients	nan	COMPLETED
Concentration of Receptors With Affinity for Cannabidiol and Cannabinol and the Effect on Chronic Orofacial Pain of Muscle Origin	nan	ENROLLING_BY_INVITATION
Prostaglandin and Cannabinoid Receptors in EoE	nan	COMPLETED
Psychological and Biological Markers of Refractory Migraine	nan	UNKNOWN
Effects of Probiotics on Gut Microbiota, Endocannabinoid and Immune Activation and Symptoms of Fatigue in Dancers	nan	COMPLETED
Biochemical Profiling of Migraine Patients	nan	RECRUITING
The Effect of Palmitylethanolamide on Central and Peripheral Sensitization After Heat-induced Hyperalgesia	nan	COMPLETED
Effect of OMM on Anandamide Levels in Saliva	nan	COMPLETED
Cytokine Production of Colonic Tissue From IBD Patients	nan	UNKNOWN
Production of Gut Microbiota-Derived Metabolites in Response to Different Fatty Acid Profiles	nan	COMPLETED
Biomarker for Farber Disease (BioFarber)	nan	WITHDRAWN
The Severe Asthma Research Program III-Boston Clinical Site	nan	COMPLETED
Observational STudy to Evaluate the EFfectiveness of OnLife® in Improving CIPN in Patients With Colon or Breast Cancer After End of Adj. Therapy	nan	COMPLETED
Dose-response Effect of Pine Nut Oil as a Dual FFA1 and FFA4 Agonist on Glucose Tolerance in Healthy Humans.	nan	COMPLETED
Gastric Bypass and Peripheral Activity of the Endocannabinoid System	nan	COMPLETED
PGE2/IL-22 Pathway in Various Forms of Eczema	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a FAAH2 binder may also engage these)

Protein	Name	Similarity
Q6DH69	—	0.987	Q6DH69 →
Q05AM4	—	0.981	Q05AM4 →
Q90578	—	0.973	Q90578 →
O08914	—	0.973	O08914 →
P97612	—	0.972	P97612 →
FAAH	Fatty-acid amide hydrolase 1	0.967	landscape →
F4KCL7	—	0.961	F4KCL7 →
Q9TUI8	—	0.961	Q9TUI8 →
Q8BX05	—	0.957	Q8BX05 →
O54695	—	0.956	O54695 →
Q6GM82	—	0.955	Q6GM82 →
Q08D86	—	0.955	Q08D86 →
Q3MHG1	—	0.955	Q3MHG1 →
Q5R514	—	0.954	Q5R514 →
Q8BGT5	—	0.954	Q8BGT5 →
Q68FH4	—	0.954	Q68FH4 →
Q01415	—	0.954	Q01415 →
O35704	—	0.953	O35704 →
Q9MUK5	—	0.953	Q9MUK5 →
D4A2H2	—	0.953	D4A2H2 →
Q9LVH5	—	0.953	Q9LVH5 →
Q99J47	—	0.952	Q99J47 →
Q5XIG6	—	0.952	Q5XIG6 →
Q5R9T5	—	0.952	Q5R9T5 →
Q60HD1	—	0.952	Q60HD1 →
P31754	—	0.952	P31754 →
Q0VFE7	—	0.952	Q0VFE7 →
Q6ZS86	—	0.951	Q6ZS86 →
Q9CZ42	—	0.951	Q9CZ42 →
Q2TAA5	—	0.951	Q2TAA5 →