Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 4/20 | 0.41 |
| ▸ | PIM1 | P11309 | 12/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PDE6D | O43924 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | PDE6A | P16499 | 1/20 | 0.35 |
| ▸ | PDE6G | P18545 | 1/20 | 0.35 |
| ▸ | PDE6B | P35913 | 1/20 | 0.35 |
| ▸ | PDE6C | P51160 | 1/20 | 0.35 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14688761 | 0.89 | DGAT1 (0.40) | CYP2A6PIM1PIM3PIM2DGAT1 | |
| SCHEMBL14689121 | 0.87 | DGAT1 (0.38) | CYP2A6PIM1PIM3PIM2DGAT1 | |
| SCHEMBL14688516 | 0.86 | PIM1 (0.49) | CYP2A6PIM1PIM3PIM2DGAT1 | |
| SCHEMBL14688835 | 0.84 | PIM1 (0.52) | CYP2A6PIM1PIM3PIM2DGAT1 | |
| SCHEMBL14713862 | 0.83 | PIM1 (0.46) | CYP2A6PIM1PIM3PIM2DGAT1 | |
| SCHEMBL14688870 | 0.83 | PIM1 (0.53) | PIM1PIM3PIM2DGAT1MAPT | |
| SCHEMBL14689482 | 0.82 | PIM1 (0.50) | PIM1PIM3PIM2DGAT1MAPT | |
| SCHEMBL14689076 | 0.82 | PIM1 (0.38) | CYP2A6PIM1PIM3PIM2DGAT1 | |
| SCHEMBL14689125 | 0.82 | PIM1 (0.41) | PIM1PIM3PIM2DGAT1 | |
| SCHEMBL14688648 | 0.81 | PIM1 (0.43) | CYP2A6PIM1PIM3PIM2DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013024002-A1 | PYRAZOLO[3,4-c]PYRIDINE COMPOUNDS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2013-02-21 | — | — | WO | disclosed |