Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.53 |
| ▸ | RAB9A | P51151 | 7/20 | 0.53 |
| ▸ | MEN1 | O00255 | 6/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.53 |
| ▸ | PKM | P14618 | 3/20 | 0.53 |
| ▸ | STAT3 | P40763 | 10/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.51 |
| ▸ | TNF | P01375 | 1/20 | 0.48 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.48 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | ATG4B | Q9Y4P1 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14715638 | 0.86 | ADORA2A (0.46) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL5498481 | 0.80 | LCK (0.57) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL14715526 | 0.77 | TAS1R3 (0.48) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL30505243 | 0.77 | MEN1 (0.65) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL14715517 | 0.75 | POLB (0.58) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL1804666 | 0.73 | NPC1 (0.76) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL14715491 | 0.73 | MAPT (0.47) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL14715473 | 0.73 | ADORA2A (0.45) | MEN1KMT2AMAPTNPSR1ALDH1A1 | |
| SCHEMBL10252930 | 0.72 | STAT3 (0.80) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL14715496 | 0.72 | PLAU (0.53) | NPC1RAB9AMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2019-10-02 | — | — | EP | disclosed |
| EP-1836174-B1 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2013-02-27 | — | — | EP | disclosed |