Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.53 |
| ▸ | EIF4H | Q15056 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CLK1 | P49759 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14715491 | 0.85 | MAPT (0.47) | POLBMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL14715519 | 0.82 | ADORA2A (0.50) | POLBMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL5494171 | 0.81 | LCK (0.69) | POLBMAPTALDH1A1HDAC6MEN1 | |
| SCHEMBL13144407 | 0.79 | ADORA3 (0.64) | MAPTALDH1A1HDAC6MEN1KMT2A | |
| SCHEMBL14715473 | 0.79 | ADORA2A (0.45) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14715533 | 0.79 | ALDH1A1 (0.58) | POLBMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL14715462 | 0.79 | ALDH1A1 (0.58) | POLBMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL14715496 | 0.78 | PLAU (0.53) | POLBMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL14715638 | 0.77 | ADORA2A (0.46) | MAPTALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL14715543 | 0.76 | LCK (0.49) | MAPTALDH1A1MEN1KMT2AADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2019-10-02 | — | — | EP | disclosed |
| EP-1836174-B1 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2013-02-27 | — | — | EP | disclosed |