Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 15/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 2/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2452496 | 0.93 | MET (0.40) | METFYN | |
| SCHEMBL2454427 | 0.92 | MET (0.43) | METPIM1FYN | |
| SCHEMBL2456961 | 0.91 | MET (0.38) | METPIM1FYNSLC5A1 | |
| SCHEMBL14715654 | 0.91 | MET (0.38) | METPIM1FYN | |
| SCHEMBL14715608 | 0.89 | MET (0.40) | METPIM1 | |
| SCHEMBL12245314 | 0.87 | MET (0.42) | METFYN | |
| SCHEMBL14715539 | 0.87 | MET (0.39) | METFYN | |
| SCHEMBL12224263 | 0.86 | MET (0.43) | METPIM1 | |
| SCHEMBL2454419 | 0.84 | MET (0.45) | MET | |
| SCHEMBL12245596 | 0.83 | FYN (0.41) | METFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367827-B1 | 3-(3-PYRIMIDINE-2-YL-BENZYL)-[1,2,4]TRIAZOLO [4,3-b]PYRIDAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-02-27 | — | — | EP | disclosed |