Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 16/20 | 0.39 |
| ▸ | FYN | P06241 | 2/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2452860 | 0.91 | MET (0.40) | METFYNCYP4F2CYP4A11 | |
| SCHEMBL14715596 | 0.90 | MET (0.40) | METFYN | |
| SCHEMBL2452496 | 0.89 | MET (0.40) | METFYN | |
| SCHEMBL14715546 | 0.87 | MET (0.41) | METFYN | |
| SCHEMBL12224215 | 0.86 | MET (0.46) | MET | |
| SCHEMBL14715581 | 0.85 | MET (0.35) | MET | |
| SCHEMBL2529553 | 0.84 | MET (0.42) | METCYP4F2CYP4A11 | |
| SCHEMBL2529534 | 0.84 | MET (0.45) | METFYN | |
| SCHEMBL2456478 | 0.82 | FYN (0.39) | METFYN | |
| SCHEMBL2458149 | 0.81 | MET (0.44) | MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367827-B1 | 3-(3-PYRIMIDINE-2-YL-BENZYL)-[1,2,4]TRIAZOLO [4,3-b]PYRIDAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-02-27 | — | — | EP | claimed |
| EP-2367827-B1 | 3-(3-PYRIMIDINE-2-YL-BENZYL)-[1,2,4]TRIAZOLO [4,3-b]PYRIDAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-02-27 | — | — | EP | disclosed |