Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 17/20 | 0.44 |
| ▸ | DRD3 | P35462 | 12/20 | 0.44 |
| ▸ | HTR1A | P08908 | 4/20 | 0.42 |
| ▸ | HTR2A | P28223 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14715570 | 0.88 | DRD2 (0.47) | DRD2DRD3 | |
| SCHEMBL3082997 | 0.87 | DRD2 (0.60) | DRD2DRD3HTR1AHTR2A | |
| SCHEMBL14715573 | 0.84 | DRD2 (0.49) | DRD2DRD3HTR1AHTR2A | |
| SCHEMBL14715656 | 0.83 | DRD2 (0.53) | DRD2DRD3HTR1AHTR2A | |
| SCHEMBL14715644 | 0.81 | DRD3 (0.56) | DRD2DRD3HTR2A | |
| SCHEMBL3087942 | 0.81 | DRD3 (0.56) | DRD2DRD3HTR2A | |
| SCHEMBL4077158 | 0.81 | DRD2 (0.55) | DRD2DRD3HTR1AHTR2APOLB | |
| SCHEMBL14715669 | 0.80 | DRD3 (0.44) | DRD2DRD3HTR2APOLB | |
| SCHEMBL3082294 | 0.79 | DRD3 (0.51) | DRD2DRD3HTR1AHTR2A | |
| SCHEMBL14715785 | 0.79 | DRD3 (0.45) | DRD2DRD3HTR1AHTR2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079693-B1 | ETHER DERIVATIVES DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | HOFFMANN LA ROCHE (CH) | 2013-02-27 | — | — | EP | claimed |