Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 10/20 | 0.60 |
| ▸ | HTR2A | P28223 | 9/20 | 0.60 |
| ▸ | CCR3 | P51677 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 5/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3077845 | 1.00 | DRD3 (0.60) | DRD3HTR2ACCR3DRD2POLB | |
| SCHEMBL14715694 | 0.89 | DRD3 (0.57) | DRD3HTR2ADRD2POLB | |
| SCHEMBL3067409 | 0.89 | DRD3 (0.57) | DRD3HTR2ADRD2POLB | |
| SCHEMBL4074116 | 0.89 | DRD2 (0.55) | DRD3HTR2ACCR3DRD2 | |
| SCHEMBL14715562 | 0.88 | DRD3 (0.58) | DRD3HTR2ACCR3DRD2POLB | |
| SCHEMBL3079396 | 0.88 | DRD3 (0.58) | DRD3HTR2ACCR3DRD2POLB | |
| SCHEMBL3085008 | 0.82 | HTR2A (0.59) | DRD3HTR2ACCR3DRD2POLB | |
| SCHEMBL4057721 | 0.82 | HTR2A (0.59) | DRD3HTR2ACCR3DRD2POLB | |
| SCHEMBL14715683 | 0.81 | DRD3 (0.43) | DRD3HTR2ADRD2 | |
| SCHEMBL14715752 | 0.80 | HTR2A (0.59) | DRD3HTR2ACCR3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079693-B1 | ETHER DERIVATIVES DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | HOFFMANN LA ROCHE (CH) | 2013-02-27 | — | — | EP | claimed |