Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 14/20 | 0.55 |
| ▸ | DRD3 | P35462 | 12/20 | 0.53 |
| ▸ | HTR2A | P28223 | 11/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | CCR3 | P51677 | 1/20 | 0.49 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.49 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.49 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14715694 | 0.91 | DRD3 (0.57) | DRD2DRD3HTR2A | |
| SCHEMBL3067409 | 0.91 | DRD3 (0.57) | DRD2DRD3HTR2A | |
| SCHEMBL14715645 | 0.89 | DRD3 (0.60) | DRD2DRD3HTR2ACCR3 | |
| SCHEMBL3077845 | 0.89 | DRD3 (0.60) | DRD2DRD3HTR2ACCR3 | |
| SCHEMBL4077158 | 0.86 | DRD2 (0.55) | DRD2DRD3HTR2AHTR1ACARM1 | |
| SCHEMBL3966402 | 0.86 | DRD2 (0.58) | DRD2DRD3HTR2AHTR1ACCR3 | |
| SCHEMBL14715683 | 0.86 | DRD3 (0.43) | DRD2DRD3HTR2A | |
| SCHEMBL4076666 | 0.83 | DRD2 (0.56) | DRD2DRD3HTR2ACCR3MCHR1 | |
| SCHEMBL3080017 | 0.82 | DRD3 (0.51) | DRD2DRD3HTR2AHTR1A | |
| SCHEMBL4065217 | 0.81 | DRD2 (0.49) | DRD2DRD3HTR2ACCR3MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079693-B1 | ETHER DERIVATIVES DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | HOFFMANN LA ROCHE (CH) | 2013-02-27 | — | — | EP | claimed |
| EP-2079693-A1 | ETHER DERIVATIVES DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | F. Hoffmann-Roche AG (CH) | 2009-07-22 | — | — | EP | claimed |
| WO-2008052899-A1 | ETHER DERIVATIVES DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-08 | — | — | WO | claimed |
| EP-2079693-B1 | ETHER DERIVATIVES DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | HOFFMANN LA ROCHE (CH) | 2013-02-27 | — | — | EP | disclosed |