Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 13/20 | 0.69 |
| ▸ | FAAH | O00519 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL14716245 | 0.86 | SMO (0.61) | SMOFAAHNPC1RAB9A | |
| SCHEMBL14716261 | 0.84 | SMO (0.65) | SMOFAAHNPC1RAB9A | |
| SCHEMBL1458340 | 0.79 | FAAH (0.51) | FAAHNPC1RAB9A | |
| SCHEMBL1458893 | 0.78 | SMO (0.72) | SMO | |
| Trifluoroacetic Acid SCHEMBL2158204 | 0.78 | SMO (0.90) | SMO | |
| Trifluoroacetic Acid SCHEMBL1460134 | 0.71 | CNR2 (0.46) | SMOFAAHNPC1RAB9A | |
| Trifluoroacetic Acid SCHEMBL14716442 | 0.71 | SMO (0.57) | SMO | |
| SCHEMBL3764185 | 0.70 | FAAH (0.71) | FAAH | |
| Hydrochloric Acid SCHEMBL1458346 | 0.69 | KDM4E (0.52) | NPC1RAB9A | |
| Trifluoroacetic Acid SCHEMBL2158258 | 0.69 | SMO (0.88) | SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130053396-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS | INSTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.R.L. (IT) | 2013-02-28 | — | — | US | claimed |
| US-20130053396-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS | INSTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.R.L. (IT) | 2013-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130053396-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS | SHH, SMO, GLI1 | SMO 2/4885FAAH 4026/4885NPC1 2969/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.