Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | KDM1A | O60341 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2730373 | 1.00 | DRD2 (0.53) | DRD2KDM1AMAOAMAOBESR2 | |
| SCHEMBL8587443 | 0.89 | CNR2 (0.55) | DRD2KDM1AMAOAMAOBESR2 | |
| SCHEMBL8585244 | 0.89 | CNR2 (0.55) | DRD2KDM1AMAOAMAOBESR2 | |
| SCHEMBL8585237 | 0.89 | CNR2 (0.55) | DRD2KDM1AMAOAMAOBESR2 | |
| SCHEMBL8585238 | 0.89 | CNR2 (0.55) | DRD2KDM1AMAOAMAOBESR2 | |
| SCHEMBL8587440 | 0.89 | CNR2 (0.55) | DRD2KDM1AMAOAMAOBESR2 | |
| SCHEMBL1506578 | 0.89 | ESR2 (0.59) | DRD2KDM1AMAOAMAOBESR2 | |
| SCHEMBL1506422 | 0.89 | ESR2 (0.59) | DRD2KDM1AMAOAMAOBESR2 | |
| SCHEMBL1506423 | 0.89 | ESR2 (0.59) | DRD2KDM1AMAOAMAOBESR2 | |
| SCHEMBL20187431 | 0.86 | KDM1A (0.52) | DRD2KDM1AMAOAMAOBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2533644-B1 | DIAZENIUMDIOLATE CYCLOPENTYL DERIVATIVES | MERCK SHARP & DOHME (US) | 2017-01-18 | — | — | EP | disclosed |
| US-8648058-B2 | Diazeniumdiolate cyclopentyl derivatives | MERCK SHARP & DOHME CORP. (US) | 2014-02-11 | — | — | US | disclosed |
| US-20130053352-A1 | DIAZENIUMDIOLATE CYCLOPENTYL DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2013-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130053352-A1 | DIAZENIUMDIOLATE CYCLOPENTYL DERIVATIVES | OR10J3, OXSR1, OXER1 | DRD2 168/4885KDM1A 3404/4885MAOA 2569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.