SCHEMBL14717838

SCHEMBL14717838

COC(=O)CCc1ccccc1Nc1ccc(-c2ccccc2)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIRT2 Q8IXJ6 1/20 0.45
MAPT P10636 7/20 0.44
KMT2A Q03164 6/20 0.44
MEN1 O00255 5/20 0.44
GAA P10253 2/20 0.44
ALDH1A1 P00352 2/20 0.44
ALOX15 P16050 1/20 0.43
PTGER4 P35408 1/20 0.43
CCNC P24863 1/20 0.42
CDK8 P49336 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
LMNA P02545 1/20 0.41
TSHR P16473 1/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
RAB9A P51151 1/20 0.40
HPGD P15428 1/20 0.40
CYP3A4 P08684 1/20 0.40
PTPN1 P18031 2/20 0.39
HTT P42858 1/20 0.39
ALOX12 P18054 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6313869 0.82 SIRT2 (0.47) SIRT2PTGER4PTPN1
SCHEMBL6308951 0.81 FFAR1 (0.56) MAPTKMT2AMEN1GAAALDH1A1
SCHEMBL3289226 0.80 FFAR1 (0.55) SIRT2ALDH1A1PTGER4LMNASMN1; SMN2
SCHEMBL5033492 0.80 PTGER4 (0.55) KMT2APTGER4CCNCCDK8TDP1
SCHEMBL6308956 0.78 SIRT2 (0.49) SIRT2KMT2AMEN1GAATDP1
SCHEMBL31310616 0.77 MAPKAPK2 (0.48) SIRT2MAPTKMT2AMEN1GAA
SCHEMBL10675188 0.77 TSHR (0.47) SIRT2MAPTKMT2AALDH1A1CCNC
SCHEMBL29013449 0.77 CYP4F2 (0.57) MAPTGAAALDH1A1TDP1SMN1; SMN2
SCHEMBL10438855 0.77 CYP4F2 (0.58) MAPTKMT2AALDH1A1CCNCCDK8
SCHEMBL10814335 0.76 PTGER4 (0.54) KMT2AALDH1A1PTGER4CCNCCDK8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9188885-B2 Reactive compound, charge transporting film, photoelectric conversion device, electrophotographic photoreceptor and method of producing the same, process cartridge, and image forming apparatus FUJI XEROX CO., LTD. (JP) 2015-11-17 US disclosed
US-20140079435-A1 NOVEL REACTIVE COMPOUND, CHARGE TRANSPORTING FILM, PHOTOELECTRIC CONVERSION DEVICE, ELECTROPHOTOGRAPHIC PHOTORECEPTOR AND METHOD OF PRODUCING THE SAME, PROCESS CARTRIDGE, AND IMAGE FORMING APPARATUS FUJI XEROX CO., LTD. (JP) 2014-03-20 US disclosed
US-8669029-B2 Reactive compound, charge transporting film, photoelectric conversion device, electrophotographic photoreceptor and method of producing the same, process cartridge, and image forming apparatus FUJI XEROX CO., LTD. (JP) 2014-03-11 US disclosed
US-20130052573-A1 NOVEL REACTIVE COMPOUND, CHARGE TRANSPORTING FILM, PHOTOELECTRIC CONVERSION DEVICE, ELECTROPHOTOGRAPHIC PHOTORECEPTOR AND METHOD OF PRODUCING THE SAME, PROCESS CARTRIDGE, AND IMAGE FORMING APPARATUS FUJI XEROX CO., LTD. (JP) 2013-02-28 US disclosed