Luvadaxistat

Luvadaxistat

SCHEMBL14719667

O=c1[nH]nc(CCc2ccc(C(F)(F)F)cc2)cc1O

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
DAO P14920 10/20 0.48
GPR84 Q9NQS5 1/20 0.46
DHODH Q02127 1/20 0.41
PARP1 P09874 2/20 0.40
NR3C2 P08235 1/20 0.40
HTR2B P41595 1/20 0.39
TAAR1 Q96RJ0 1/20 0.39
COMT P21964 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14718548 0.87 DAO (0.47) DAOGPR84DHODHPARP1
SCHEMBL16231718 0.86 GPR84 (0.49) DAOGPR84DHODHPARP1
SCHEMBL14718895 0.85 DAO (0.51) DAODHODHPARP1NR3C2HTR2B
SCHEMBL30107675 0.85 DAO (0.51) DAODHODHPARP1NR3C2HTR2B
SCHEMBL14719236 0.84 DAO (0.57) DAOGPR84
SCHEMBL18467392 0.84 ESR1 (0.45) DAOPARP1HTR2B
SCHEMBL30107626 0.84 DAO (0.56) DAOGPR84COMT
SCHEMBL14719044 0.84 DAO (0.50) DAOGPR84PARP1NR3C2
SCHEMBL14718871 0.84 DAO (0.56) DAOGPR84COMT
SCHEMBL14719582 0.83 GPR84 (0.52) DAOGPR84DHODH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 103 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12186313-B2 Pyridazinone compounds and their use as DAAO inhibitors TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2025-01-07 US claimed
US-20240036064-A1 METHODS AND COMPOSITIONS FOR DETECTING COGNITIVE DISORDER Sanford Burnham Prebys Medical Discovery Institute 2024-02-01 US claimed
CN-115666526-A Oral solid preparation 武田药品工业株式会社 2023-01-31 CN claimed
EP-4114361-A1 ORAL SOLID PREPARATIONS Takeda Pharmaceutical Company Limited (JP) 2023-01-11 EP claimed
US-20220008416-A1 PYRIDAZINONE COMPOUNDS AND THEIR USE AS DAAO INHIBITORS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2022-01-13 US claimed
US-11129828-B2 Pyridazinone compounds and their use as DAAO inhibitors TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2021-09-28 US claimed
US-20200121678-A1 PYRIDAZINONE COMPOUNDS AND THEIR USE AS DAAO INHIBITORS TAKEDA PHARMACEUTICALS CO (JP) 2020-04-23 US claimed
US-10463663-B2 Pyridazinone compounds and their use as DAAO inhibitors TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2019-11-05 US claimed
US-20180177780-A1 PYRIDAZINONE COMPOUNDS AND THEIR USE AS DAAO INHIBITORS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2018-06-28 US claimed
EP-3113778-B1 PYRIDAZINE DERIVATIVES FOR USE IN THE PREVENTION OR TREATMENT OF AN ATAXIC DISORDER TAKEDA PHARMACEUTICALS CO (JP) 2018-06-06 EP claimed
EP-3113778-A1 PYRIDAZINE DERIVATIVES FOR USE IN THE PREVENTION OR TREATMENT OF AN ATAXIC DISORDER Takeda Pharmaceutical Company Limited (JP) 2017-01-11 EP claimed
CN-106102743-A For preventing or treating the pyridyl derivatives of incoordination illness 武田药品工业株式会社 2016-11-09 CN claimed
US-9290456-B2 Pyridazinone compounds and their use as DAAO inhibitors TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-03-22 US claimed
EP-2748149-B1 PYRIDAZINONE COMPOUNDS AND THEIR USE AS DAAO INHIBITORS TAKEDA PHARMACEUTICAL (JP) 2015-10-21 EP claimed
WO-2015132608-A1 PYRIDAZINE DERIVATIVES FOR USE IN THE PREVENTION OR TREATMENT OF AN ATAXIC DISORDER TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-09-11 WO claimed
US-20150030704-A1 PYRIDAZINONE COMPOUNDS AND THEIR USE AS DAAO INHIBITORS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-01-29 US claimed
US-20140336165-A1 DIHYDROXY AROMATIC HETEROCYCLIC COMPOUND ASTELLAS PHARMA INC. (JP) 2014-11-13 US claimed
EP-2748149-A1 PYRIDAZINONE COMPOUNDS AND THEIR USE AS DAAO INHIBITORS Takeda Pharmaceutical Company Limited (JP) 2014-07-02 EP claimed
WO-2013027000-A1 PYRIDAZINONE COMPOUNDS AND THEIR USE AS DAAO INHIBITORS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-02-28 WO claimed
US-20130052281-A1 NOVEL COMPOUNDS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-02-28 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130052281-A1 NOVEL COMPOUNDS ABCG2, F12, UGT1A1 DAO 4565/4885GPR84 826/4885DHODH 2119/4885
US-20150030704-A1 PYRIDAZINONE COMPOUNDS AND THEIR USE AS DAAO INHIBITORS PNPO, DAO, DPYD DAO 2/4885GPR84 2658/4885DHODH 9/4885
US-12186313-B2 Pyridazinone compounds and their use as DAAO inhibitors PNPO, DAO, DPYD DAO 2/4885GPR84 2658/4885DHODH 9/4885
US-20200121678-A1 PYRIDAZINONE COMPOUNDS AND THEIR USE AS DAAO INHIBITORS PNPO, DAO, DPYD DAO 2/4885GPR84 2658/4885DHODH 9/4885
US-11129828-B2 Pyridazinone compounds and their use as DAAO inhibitors PNPO, DAO, DPYD DAO 2/4885GPR84 2658/4885DHODH 9/4885
US-20180177780-A1 PYRIDAZINONE COMPOUNDS AND THEIR USE AS DAAO INHIBITORS PNPO, DAO, DPYD DAO 2/4885GPR84 2658/4885DHODH 9/4885
US-10463663-B2 Pyridazinone compounds and their use as DAAO inhibitors PNPO, DAO, DPYD DAO 2/4885GPR84 2658/4885DHODH 9/4885
US-20140336165-A1 DIHYDROXY AROMATIC HETEROCYCLIC COMPOUND DAO, DDO, DDC DAO 1/4885GPR84 717/4885DHODH 5/4885
US-20220008416-A1 PYRIDAZINONE COMPOUNDS AND THEIR USE AS DAAO INHIBITORS PNPO, DAO, DPYD DAO 2/4885GPR84 2658/4885DHODH 9/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.