SCHEMBL1471992

SCHEMBL1471992

O=C(CCCCCCc1ccccc1)c1ncc(-c2cccc(F)c2)o1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FAAH O00519 19/20 1.00
CES1 P23141 3/20 0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1471899 0.89 FAAH (1.00) FAAHCES1
SCHEMBL1471183 0.88 FAAH (1.00) FAAHCES1
SCHEMBL1472223 0.87 FAAH (1.00) FAAHCES1
SCHEMBL12827980 0.87 FAAH (0.78) FAAHCES1
SCHEMBL1471244 0.87 FAAH (1.00) FAAHCES1
SCHEMBL12749482 0.85 FAAH (1.00) FAAHCES1
SCHEMBL1471916 0.85 FAAH (1.00) FAAHCES1
SCHEMBL1472126 0.84 FAAH (1.00) FAAHCES1
SCHEMBL12749420 0.84 FAAH (0.74) FAAHCES1
SCHEMBL1472138 0.84 FAAH (1.00) FAAHCES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1983994-B1 OXAZOLE KETONES AS MODULATORS OF FATTY ACID AMIDE HYDROLASE SCRIPPS RESEARCH INST (US) 2015-09-30 EP claimed
EP-1983994-A2 OXAZOLE KETONES AS MODULATORS OF FATTY ACID AMIDE HYDROLASE The Scripps Research Institute (US) 2008-10-29 EP claimed
WO-2007098142-A2 OXAZOLE KETONES AS MODULATORS OF FATTY ACID AMIDE HYDROLASE THE SCRIPPS RESEARCH INSTITUTE (US) 2007-08-30 WO claimed
US-20070203156-A1 Oxazole ketones as modulators of fatty acid amide hydrolase THE SCRIPPS RESEARCH INSTITUTE (US) 2007-08-30 US claimed
EP-1983994-B1 OXAZOLE KETONES AS MODULATORS OF FATTY ACID AMIDE HYDROLASE SCRIPPS RESEARCH INST (US) 2015-09-30 EP disclosed
US-7915270-B2 Oxazole ketones as modulators of fatty acid amide hydrolase THE SCRIPPS RESEARCH INSTITUTE (US) 2011-03-29 US disclosed
US-7915270-B2 Oxazole ketones as modulators of fatty acid amide hydrolase THE SCRIPPS RESEARCH INSTITUTE (US) 2011-03-29 US disclosed
US-7915270-B2 Oxazole ketones as modulators of fatty acid amide hydrolase THE SCRIPPS RESEARCH INSTITUTE (US) 2011-03-29 US disclosed
EP-1983994-A2 OXAZOLE KETONES AS MODULATORS OF FATTY ACID AMIDE HYDROLASE The Scripps Research Institute (US) 2008-10-29 EP disclosed
WO-2007098142-A2 OXAZOLE KETONES AS MODULATORS OF FATTY ACID AMIDE HYDROLASE THE SCRIPPS RESEARCH INSTITUTE (US) 2007-08-30 WO disclosed
WO-2007098142-A2 OXAZOLE KETONES AS MODULATORS OF FATTY ACID AMIDE HYDROLASE THE SCRIPPS RESEARCH INSTITUTE (US) 2007-08-30 WO disclosed
US-20070203156-A1 Oxazole ketones as modulators of fatty acid amide hydrolase THE SCRIPPS RESEARCH INSTITUTE (US) 2007-08-30 US disclosed
US-20070203156-A1 Oxazole ketones as modulators of fatty acid amide hydrolase THE SCRIPPS RESEARCH INSTITUTE (US) 2007-08-30 US disclosed
US-20070203156-A1 Oxazole ketones as modulators of fatty acid amide hydrolase THE SCRIPPS RESEARCH INSTITUTE (US) 2007-08-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070203156-A1 Oxazole ketones as modulators of fatty acid amide hydrolase FAAH, FAAH2, HCRTR2 FAAH 1/4885CES1 81/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.