Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.42 |
| ▸ | ACP3 | P15309 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6445960 | 0.90 | CTNNB1 (0.46) | CTNNB1CYP1A2CYP2C19CYP2C9CYP2D6 | |
| SCHEMBL27627250 | 0.81 | CYP1A2 (0.46) | CTNNB1CYP1A2CYP2C19CYP2C9CYP2D6 | |
| SCHEMBL11567192 | 0.81 | CTNNB1 (0.45) | CTNNB1CYP1A2CYP2C19CYP2C9CYP2D6 | |
| SCHEMBL31450593 | 0.81 | CTNNB1 (0.49) | CTNNB1CYP1A2CYP2C19CYP2C9CYP2D6 | |
| SCHEMBL15096098 | 0.81 | CTNNB1 (0.49) | CTNNB1CYP1A2CYP2C19CYP2C9CYP2D6 | |
| SCHEMBL15096099 | 0.81 | CTNNB1 (0.49) | CTNNB1CYP1A2CYP2C19CYP2C9CYP2D6 | |
| SCHEMBL197908 | 0.81 | CTNNB1 (0.49) | CTNNB1CYP1A2CYP2C19CYP2C9CYP2D6 | |
| SCHEMBL6445137 | 0.81 | CTNNB1 (0.45) | CTNNB1CYP1A2CYP2C19CYP2C9CYP2D6 | |
| SCHEMBL28978071 | 0.79 | PIP4K2A (0.47) | CTNNB1CYP1A2CYP2C19CYP2C9CYP2D6 | |
| SCHEMBL8903464 | 0.79 | SIGMAR1 (0.43) | CYP1A2CYP2C19CYP2C9CYP2D6TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9096605-B2 | Pyrazolopyrimidine derivatives as PI3 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2015-08-04 | — | — | US | disclosed |
| US-20140187545-A1 | Pyrazolopyrimidine Derivatives As PI3 Kinase Inhibitors | GLAXOSMITHKLINE LLC (US) | 2014-07-03 | — | — | US | disclosed |
| WO-2013028263-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AS PI3 KINASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140187545-A1 | Pyrazolopyrimidine Derivatives As PI3 Kinase Inhibitors | PI4KB, PIK3CA, PI4K2B | CTNNB1 868/4885CYP1A2 4287/4885CYP2C19 3289/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.