Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | USP5 | P45974 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14720415 | 0.90 | DRD2 (0.38) | MAP2K1DRD2DRD4DRD3RAB9A | |
| SCHEMBL14720417 | 0.83 | HDAC3 (0.41) | NPC1RAB9AKMT2AALDH1A1LMNA | |
| SCHEMBL14720555 | 0.81 | FASN (0.37) | TMEM97SIGMAR1USP30KMT2ADGAT1 | |
| SCHEMBL5630504 | 0.78 | MAP2K1 (0.57) | MAP2K1TMEM97SIGMAR1DRD2DRD4 | |
| SCHEMBL22227216 | 0.73 | MAP2K1 (0.47) | MAP2K1TMEM97SIGMAR1USP30DRD2 | |
| SCHEMBL14720615 | 0.71 | DRD2 (0.50) | MAP2K1TMEM97SIGMAR1USP30DRD2 | |
| SCHEMBL12121083 | 0.69 | CNR2 (0.55) | MAP2K1CNR2NPC1RAB9ACHRM4 | |
| SCHEMBL3346723 | 0.68 | DGAT1 (0.54) | TMEM97SIGMAR1USP30PPARDNPC1 | |
| SCHEMBL27766092 | 0.68 | DGAT1 (0.51) | MAP2K1TMEM97SIGMAR1USP30PPARD | |
| SCHEMBL26838419 | 0.68 | TMEM97 (0.59) | TMEM97SIGMAR1PPARDNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013028445-A1 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-02-28 | — | — | WO | disclosed |