Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 18/20 | 0.71 |
| ▸ | CES1 | P23141 | 3/20 | 0.50 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1474042 | 0.85 | FAAH (0.69) | FAAHCES1 | |
| SCHEMBL1474043 | 0.84 | FAAH (0.69) | FAAHCES1 | |
| SCHEMBL1471208 | 0.84 | FAAH (0.69) | FAAHCES1 | |
| SCHEMBL13478065 | 0.84 | FAAH (0.65) | FAAHCES1ASAH1HDAC1HDAC6 | |
| SCHEMBL1471366 | 0.83 | FAAH (0.71) | FAAHCES1ASAH1HDAC1HDAC6 | |
| SCHEMBL1471971 | 0.83 | FAAH (0.73) | FAAHCES1 | |
| SCHEMBL1472158 | 0.83 | FAAH (1.00) | FAAHCES1 | |
| SCHEMBL3043528 | 0.82 | FAAH (0.63) | FAAHCES1ASAH1HDAC1HDAC6 | |
| SCHEMBL1471593 | 0.81 | FAAH (0.74) | FAAHCES1ASAH1HDAC1HDAC6 | |
| SCHEMBL1471635 | 0.80 | FAAH (0.73) | FAAHCES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1983994-B1 | OXAZOLE KETONES AS MODULATORS OF FATTY ACID AMIDE HYDROLASE | SCRIPPS RESEARCH INST (US) | 2015-09-30 | — | — | EP | claimed |
| US-7915270-B2 | Oxazole ketones as modulators of fatty acid amide hydrolase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-03-29 | — | — | US | claimed |