Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.35 |
| ▸ | TTR | P02766 | 2/20 | 0.35 |
| ▸ | TYMS | P04818 | 1/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | P2RY6 | Q15077 | 2/20 | 0.32 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27622986 | 0.72 | ALDH1A1 (0.60) | TDP1TSHRALDH1A1MAPT | |
| SCHEMBL27573661 | 0.72 | TDP1 (0.68) | TDP1ATMVCAM1TSHRALDH1A1 | |
| SCHEMBL12066584 | 0.71 | TDP1 (0.52) | TDP1ATMVCAM1TSHRALDH1A1 | |
| SCHEMBL5008892 | 0.67 | TDP1 (0.42) | TDP1ATMTSHRALDH1A1MAPT | |
| SCHEMBL18496986 | 0.67 | ATM (0.48) | TDP1ATMVCAM1ALDH1A1HIF1A | |
| SCHEMBL1822002 | 0.67 | TDP1 (0.61) | TDP1ATMVCAM1TSHRALDH1A1 | |
| SCHEMBL4748223 | 0.67 | TDP1 (0.54) | TDP1ATMVCAM1TSHRALDH1A1 | |
| SCHEMBL3286500 | 0.67 | GPR35 (0.61) | TDP1ATMALDH1A1HIF1ATTR | |
| SCHEMBL7784325 | 0.67 | ALDH1A1 (0.50) | TDP1ATMTSHRALDH1A1HIF1A | |
| SCHEMBL31399720 | 0.66 | TDP1 (0.40) | TDP1ATMVCAM1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013028495-A1 | DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY (ADP-RIBOSE) POLYMERASE (PARP) FOR THE TREATMENT OF MULTIPLE MYELOMA | BIOMARIN PHARMACEUTICAL INC. (US) | 2013-02-28 | — | — | WO | disclosed |