SCHEMBL14720518

SCHEMBL14720518

C(=C1CCN(C2CCC2)CC1)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 6/20 0.46
SLC18A3 Q16572 1/20 0.45
L3MBTL3 Q96JM7 2/20 0.42
L3MBTL1 Q9Y468 2/20 0.42
MBTD1 Q05BQ5 1/20 0.42
CYP2D6 P10635 3/20 0.42
CHRNB2 P17787 1/20 0.40
CHRNB4 P30926 1/20 0.40
CHRNA3 P32297 1/20 0.40
CHRNA4 P43681 1/20 0.40
CHRNA7 P36544 1/20 0.40
ALDH1A1 P00352 1/20 0.40
GRIN2B Q13224 2/20 0.39
CYP2C19 P33261 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14720608 0.83 HRH3 (0.43) HRH3L3MBTL3L3MBTL1MBTD1CHRNA7
SCHEMBL14721775 0.83 HRH3 (0.43) HRH3SLC18A3L3MBTL3L3MBTL1MBTD1
SCHEMBL14720720 0.82 SRD5A2 (0.58) HRH3L3MBTL3L3MBTL1MBTD1ALDH1A1
Hydrochloric Acid SCHEMBL14721345 0.81 SRD5A2 (0.57) HRH3L3MBTL3L3MBTL1MBTD1ALDH1A1
SCHEMBL14721063 0.80 HRH3 (0.47) HRH3SLC18A3L3MBTL3L3MBTL1MBTD1
SCHEMBL14720920 0.80 HRH3 (0.47) HRH3SLC18A3L3MBTL3L3MBTL1MBTD1
SCHEMBL14721067 0.80 SRD5A2 (0.42) HRH3L3MBTL3L3MBTL1CYP2D6ALDH1A1
SCHEMBL14722836 0.80 HRH3 (0.41) HRH3L3MBTL3L3MBTL1MBTD1CHRNA7
SCHEMBL14720496 0.80 HRH3 (0.41) HRH3SLC18A3L3MBTL3L3MBTL1CYP2D6
SCHEMBL14720522 0.77 HRH3 (0.39) HRH3L3MBTL3MBTD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013027001-A1 COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-02-28 WO disclosed
WO-2013027001-A1 COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-02-28 WO disclosed