Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 8/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20333309 | 0.84 | MCHR1 (0.46) | MCHR1CCR2MAOBHTR2AHTR2C | |
| SCHEMBL20305006 | 0.80 | SRD5A2 (0.54) | MCHR1HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL14721386 | 0.79 | GPR183 (0.49) | MCHR1 | |
| SCHEMBL20304836 | 0.76 | MCHR1 (0.54) | MCHR1THRB | |
| SCHEMBL14720870 | 0.76 | MCHR1 (0.52) | MCHR1HTR7HTR2AHTR2C | |
| SCHEMBL14721932 | 0.74 | GPR183 (0.45) | MCHR1 | |
| SCHEMBL14720920 | 0.73 | HRH3 (0.47) | MCHR1KCNH2HTR7 | |
| SCHEMBL14720608 | 0.73 | HRH3 (0.43) | MCHR1KCNH2MAOB | |
| SCHEMBL12891140 | 0.73 | MAOA (0.45) | MAOB | |
| SCHEMBL14720741 | 0.71 | OPRM1 (0.44) | MCHR1HTR2CSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |