Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14720817 | 0.87 | SRD5A2 (0.43) | SRD5A2NPC1RAB9APOLBALDH1A1 | |
| SCHEMBL14720988 | 0.83 | SRD5A2 (0.49) | SRD5A2NPC1RAB9APOLBALDH1A1 | |
| SCHEMBL14721400 | 0.83 | SRD5A2 (0.48) | SRD5A2POLBALDH1A1KMT2AKDM4E | |
| SCHEMBL14731083 | 0.82 | SRD5A2 (0.46) | SRD5A2NPC1RAB9APOLBALDH1A1 | |
| SCHEMBL14720873 | 0.81 | ALDH1A1 (0.54) | SRD5A2NPC1ALDH1A1KMT2AKDM4E | |
| SCHEMBL14720838 | 0.79 | SRD5A2 (0.44) | SRD5A2ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL14721067 | 0.79 | SRD5A2 (0.42) | SRD5A2ALDH1A1KDM4ECYP2D6L3MBTL1 | |
| SCHEMBL14731157 | 0.78 | SRD5A2 (0.37) | SRD5A2ALDH1A1KMT2AEPHX2LMNA | |
| SCHEMBL14720886 | 0.78 | ALDH1A1 (0.50) | SRD5A2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL14720430 | 0.76 | SRD5A2 (0.43) | SRD5A2POLBALDH1A1KMT2ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | claimed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |