SCHEMBL14720873

SCHEMBL14720873

O=C(Cc1ccc(C=C2CCN(C3CCC3)CC2)cc1)N1CCCC1

nearest known ligand 0.54

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.54
KDM4E B2RXH2 2/20 0.54
SRD5A2 P31213 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.47
NPC1 O15118 1/20 0.47
HPGD P15428 1/20 0.47
SRD5A1 P18405 1/20 0.44
L3MBTL3 Q96JM7 4/20 0.44
PKM P14618 1/20 0.42
ACACB O00763 1/20 0.41
ACACA Q13085 1/20 0.41
TPSAB1 Q15661 2/20 0.40
TPSD1 Q9BZJ3 2/20 0.40
TPSG1 Q9NRR2 2/20 0.40
PRSS1 P07477 1/20 0.40
ECE2 P0DPD6 1/20 0.40
L3MBTL1 Q9Y468 4/20 0.39
TSHR P16473 1/20 0.39
KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14721400 0.85 SRD5A2 (0.48) ALDH1A1KDM4ESRD5A2SRD5A1L3MBTL3
SCHEMBL14731083 0.82 SRD5A2 (0.46) ALDH1A1KDM4ESRD5A2SMN1; SMN2NPC1
SCHEMBL14720637 0.81 L3MBTL3 (0.62) ALDH1A1KDM4EL3MBTL3L3MBTL1KMT2A
SCHEMBL14720677 0.81 SRD5A2 (0.50) ALDH1A1KDM4ESRD5A2NPC1L3MBTL1
SCHEMBL14721067 0.80 SRD5A2 (0.42) ALDH1A1KDM4ESRD5A2HPGDSRD5A1
SCHEMBL14720430 0.78 SRD5A2 (0.43) ALDH1A1KDM4ESRD5A2SRD5A1TSHR
SCHEMBL14720838 0.78 SRD5A2 (0.44) ALDH1A1KDM4ESRD5A2HPGDSRD5A1
SCHEMBL14720882 0.78 SRD5A2 (0.43) ALDH1A1KDM4ESRD5A2SMN1; SMN2NPC1
SCHEMBL14720575 0.77 L3MBTL3 (0.51) ALDH1A1KDM4EL3MBTL3L3MBTL1KMT2A
SCHEMBL14720720 0.77 SRD5A2 (0.58) ALDH1A1SRD5A2HPGDSRD5A1L3MBTL3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013027001-A1 COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-02-28 WO claimed
WO-2013027001-A1 COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-02-28 WO disclosed