Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.38 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | OGA | O60502 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14720922 | 0.87 | DRD3 (0.53) | HRH3RAB9AKCNJ1KCNH2DRD2 | |
| SCHEMBL1483704 | 0.83 | RAB9A (0.53) | HRH3RAB9AKCNJ1KCNH2DRD2 | |
| SCHEMBL2514685 | 0.81 | HRH3 (0.52) | HRH3DRD2DRD3ALDH1A1 | |
| SCHEMBL14721386 | 0.80 | GPR183 (0.49) | HRH3DRD3OGA | |
| SCHEMBL14721028 | 0.80 | HRH3 (0.45) | HRH3CYP2A6ALDH1A1KDM4ELMNA | |
| SCHEMBL18741389 | 0.80 | HRH3 (0.47) | HRH3DRD2ALDH1A1KDM4EGAA | |
| SCHEMBL14720404 | 0.75 | ALDH1A1 (0.46) | MAOBALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL14721932 | 0.75 | GPR183 (0.45) | HRH3DRD3OGA | |
| SCHEMBL14722734 | 0.75 | OGA (0.52) | HRH3ALDH1A1KDM4ELMNAOGA | |
| SCHEMBL376663 | 0.73 | KDM4E (0.67) | DRD2DRD3MAOBCHRNA10CHRNA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |