Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | RORC | P51449 | 7/20 | 0.38 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14720872 | 0.78 | ALDH1A1 (0.50) | HSD17B10KMT2AHTR2AHTR2CMEN1 | |
| SCHEMBL14722546 | 0.72 | USP2 (0.45) | USP2HPGDHSD17B10RORCPTGDR | |
| SCHEMBL1510278 | 0.71 | MEN1 (0.38) | USP2HPGDHSD17B10RORCKMT2A | |
| SCHEMBL1510279 | 0.71 | MEN1 (0.38) | USP2HPGDHSD17B10RORCKMT2A | |
| SCHEMBL16826403 | 0.70 | CHIA (0.46) | USP2HPGDHSD17B10RORCJAK2 | |
| SCHEMBL25353462 | 0.68 | KDM1A (0.38) | POLBKMT2AMEN1HTTALDH1A1 | |
| SCHEMBL3469273 | 0.68 | HTR2A (0.54) | USP2HPGDHSD17B10HTR2AHTR2C | |
| SCHEMBL4770454 | 0.68 | CNR2 (0.49) | RORCPOLBTSHRHTTL3MBTL1 | |
| SCHEMBL25356320 | 0.67 | KDM1A (0.37) | POLBKMT2AMEN1HTT | |
| SCHEMBL25356323 | 0.66 | KDM1A (0.36) | POLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |