Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14720772 | 0.91 | HRH3 (0.37) | SRD5A2POLBHRH3 | |
| SCHEMBL14720789 | 0.91 | HRH3 (0.37) | SRD5A2POLBHRH3SRD5A1CYP2D6 | |
| SCHEMBL14720504 | 0.88 | HRH3 (0.35) | SRD5A2POLBHRH3 | |
| SCHEMBL14720597 | 0.88 | POLB (0.38) | SRD5A2POLBHRH3CYP2D6KDM4E | |
| SCHEMBL14720505 | 0.88 | HRH3 (0.35) | SRD5A2POLBHRH3 | |
| SCHEMBL14720796 | 0.87 | SRD5A2 (0.39) | SRD5A2POLBHRH3SRD5A1ALDH1A1 | |
| SCHEMBL14720667 | 0.86 | SRD5A2 (0.34) | SRD5A2POLBHRH3 | |
| SCHEMBL14723599 | 0.82 | HRH3 (0.43) | SRD5A2POLBHRH3OPRM1OPRD1 | |
| SCHEMBL14721067 | 0.81 | SRD5A2 (0.42) | SRD5A2HRH3SRD5A1CYP2D6KDM4E | |
| SCHEMBL14721332 | 0.81 | HRH3 (0.39) | SRD5A2HRH3OPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | claimed |