Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GPR4 | P46093 | 3/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14720796 | 0.86 | SRD5A2 (0.39) | HRH3POLBSRD5A2 | |
| SCHEMBL1790521 | 0.83 | HRH3 (0.48) | HRH3GPR4GPR119 | |
| SCHEMBL14720924 | 0.82 | SRD5A2 (0.38) | HRH3POLBOPRM1OPRD1SRD5A2 | |
| SCHEMBL14720597 | 0.79 | POLB (0.38) | HRH3POLBSRD5A2TSHR | |
| SCHEMBL14723601 | 0.78 | POLB (0.37) | HRH3POLBSRD5A2 | |
| SCHEMBL14720789 | 0.78 | HRH3 (0.37) | HRH3POLBSRD5A2 | |
| SCHEMBL14720772 | 0.78 | HRH3 (0.37) | HRH3POLBSRD5A2 | |
| SCHEMBL14720504 | 0.75 | HRH3 (0.35) | HRH3POLBSRD5A2 | |
| SCHEMBL14720505 | 0.75 | HRH3 (0.35) | HRH3POLBSRD5A2 | |
| SCHEMBL14720667 | 0.74 | SRD5A2 (0.34) | HRH3POLBSRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |