Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.38 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.35 |
| ▸ | OGA | O60502 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14721266 | 0.84 | SRD5A1 (0.40) | SRD5A1SRD5A2HDAC4HDAC6OGA | |
| SCHEMBL14720749 | 0.84 | SRD5A1 (0.58) | SRD5A1SRD5A2GRM5GPR119ESR2 | |
| SCHEMBL14720589 | 0.81 | GRM5 (0.43) | SRD5A1SRD5A2GRM5GPR119ESR2 | |
| SCHEMBL18992022 | 0.80 | OGA (0.45) | SRD5A1SRD5A2GRM5GPR119ESR2 | |
| SCHEMBL15699606 | 0.78 | ALDH1A1 (0.54) | GRM5GPR119ABCB1LMNAMAPT | |
| SCHEMBL14720430 | 0.77 | SRD5A2 (0.43) | SRD5A1SRD5A2HDAC4HDAC6KMT2A | |
| SCHEMBL14720714 | 0.77 | HDAC6 (0.39) | SRD5A1SRD5A2HDAC4HDAC6SMN1; SMN2 | |
| SCHEMBL14720896 | 0.77 | GRM5 (0.46) | GRM5GPR119ESR2LMNAMAPT | |
| SCHEMBL5497099 | 0.77 | MEN1 (0.55) | GRM5ESR2LMNAMEN1KMT2A | |
| SCHEMBL4635083 | 0.77 | GRM5 (0.46) | GRM5GPR119ESR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |