Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.49 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 3/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14722542 | 0.82 | DAO (0.49) | DAO | |
| SCHEMBL14722466 | 0.79 | DAO (0.46) | DAO | |
| SCHEMBL14722008 | 0.78 | DAO (0.42) | DAO | |
| SCHEMBL14722688 | 0.76 | DAO (0.48) | DAOP2RX7 | |
| SCHEMBL14718360 | 0.73 | DAO (0.48) | DAONR3C2HTR2AHTR2CGSK3B | |
| SCHEMBL30159648 | 0.73 | DAO (0.48) | DAONR3C2HTR2AHTR2CGSK3B | |
| SCHEMBL7700904 | 0.72 | IDO1 (0.58) | DAONR3C2HTR2AHTR2CMAOB | |
| SCHEMBL6371731 | 0.68 | MAPK14 (0.58) | — | |
| SCHEMBL22941169 | 0.67 | MPO (0.48) | DAOP2RX7 | |
| SCHEMBL15577532 | 0.66 | PIK3CA (0.55) | GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2748149-A1 | PYRIDAZINONE COMPOUNDS AND THEIR USE AS DAAO INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2014-07-02 | — | — | EP | disclosed |
| WO-2013027000-A1 | PYRIDAZINONE COMPOUNDS AND THEIR USE AS DAAO INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |