Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | BCL9 | O00512 | 1/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7188600 | 0.87 | MAPT (0.55) | MAPTKMT2ATSHRALDH1A1TDP1 | |
| SCHEMBL5024676 | 0.87 | MAPT (0.52) | MAPTKMT2ATSHRALDH1A1TDP1 | |
| SCHEMBL9503602 | 0.86 | MAPT (0.56) | MAPTKMT2ATSHRALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL6988461 | 0.85 | MAPT (0.54) | MAPTKMT2ATSHRALDH1A1TDP1 | |
| SCHEMBL15154022 | 0.83 | MAPT (0.54) | MAPTKMT2ATSHRALDH1A1TDP1 | |
| SCHEMBL14075558 | 0.83 | MAPT (0.54) | MAPTKMT2ATSHRALDH1A1TDP1 | |
| SCHEMBL1350599 | 0.83 | MAPT (0.55) | MAPTKMT2ATSHRALDH1A1TDP1 | |
| SCHEMBL5708169 | 0.83 | MAPT (0.49) | MAPTKMT2ATSHRALDH1A1TDP1 | |
| SCHEMBL27869674 | 0.82 | ALDH1A1 (0.56) | MAPTKMT2ATSHRALDH1A1TDP1 | |
| SCHEMBL5708161 | 0.82 | ALDH1A1 (0.67) | MAPTKMT2AALDH1A1KCNJ1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8383817-B2 | S-(+)-2 beta -hydroxymethyl-3 alpha -[bis(4-fluorophenyl)methoxy]tropane; treating mental disorders; reducing food intake; detecting the binding of the compound to the central nervous system tissue to monitor Parkinson's | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2013-02-26 | — | — | US | disclosed |